Rasburicase
From SNPedia
Rasburicase, sold under trade names including Elitek, Fasturtec, and Rasuritek, is a medication that helps to clear uric acid from the blood.Wikipedia A pegylated form of rasburicase, pegloticase, is also FDA-approved for the treatment of refractory gout.
Both rasburicase and pegloticase carry FDA and EMA warnings indicating that they should not be used in patients with G6PD-deficiency.
| Genotype/Genoset | Diplotype | Gene | Drug Use/Category/Class | Medical Field | Summary | Descriptive Sentence |
|---|---|---|---|---|---|---|
| gs309 | WT/WT | G6PD | Leukemia; Gout | Oncology; Rheumatology | Normal Response Expected | You do not appear to carry any G6PD mutations linked to an unwanted side effect (hemolytic anemia and methemoglobinemia). |
| gs307 | Carrier | G6PD | Leukemia; Gout | Oncology; Rheumatology | Use with Caution | You carry a G6PD mutation that might lead to an unwanted side effect (hemolytic anemia and methemoglobinemia) when taking rasburicase; due to variable expression (i.e. in females), enzymatic testing for G6PD activity is advisable. |
| gs308 | G6PD-deficient | G6PD | Leukemia; Gout | Oncology; Rheumatology | Avoid Use | You carry a G6PD mutation linked to an unwanted side effect (hemolytic anemia and methemoglobinemia) when taking rasburicase; rasburicaseshould not be prescribed for you according to the FDA. |
