||1.5x risk of Crohn's disease
||1.9x risk of Crohn's disease
|?|| (C;C) (C;T) (T;T) ||28|
rs1000113 has been reported in a large study to be associated with Crohn's disease.
The risk allele (oriented to the dbSNP entry) is (T); the odds ratio associated with heterozygotes is 1.54 (CI 1.31-1.82), and for homozygotes, 1.92 (CI 0.92-4.00). [PMID 17554300]
[PMID 18224312] Pharmacogenetics: data, concepts and tools to improve drug discovery and drug treatment.
[PMID 19098858] Polymorphism of the IRGM gene might predispose to fistulizing behavior in Crohn's disease.
[PMID 20106866] Independent and population-specific association of risk variants at the IRGM locus with Crohn's disease.