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rs10011796

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 0 common/normal (in most populations)
(C;T) 2 Less response to allopurinol in Caucasians with gout
(T;T) 2 Less response to allopurinol in Caucasians with gout
is asnp
is mentioned by
dbSNPrs10011796
dbSNP (classic)rs10011796
ClinGenrs10011796
ebirs10011796
HLIrs10011796
Exacrs10011796
Gnomadrs10011796
Varsomers10011796
LitVarrs10011796
Maprs10011796
PheGenIrs10011796
Biobankrs10011796
1000 genomesrs10011796
hgdprs10011796
ensemblrs10011796
geneviewrs10011796
scholarrs10011796
googlers10011796
pharmgkbrs10011796
gwascentralrs10011796
openSNPrs10011796
23andMers10011796
23andMe allrs10011796
SNPshotrs10011796
SNPdbers10011796
MSV3drs10011796
GWAS Ctlgrs10011796
Max Magnitude2

rs10011796 represents a variant in the ABCG2 gene on chromosome 4. In most (but not all) populations, the minor allele is (T). It is genetically independent of rs2231142, a different ABCG2 gene variant that has been linked to gout in several populations.

A 2015 GWAS study of allopurinol response reported that in non-Hispanic whites, rs10011796(T) showed the strongest statistical association. When other ethnicities were included in a meta-analysis, the association remained significant but weakened somewhat (from p = 2x10e−8 to 7x10e−4).[PMID 25676789OA-icon.png]

In 2017, rs10011796 was reported to be associated with tophi development in gout patients of Western Polynesian (but not Eastern Polynesian) origin. The authors suggest that the ancestry-specific effects of ABCG2 variants may be due to haplotype backgrounds.[PMID 28270222OA-icon.png]