|?|| (A;A) (A;C) (C;C) ||28|
|Desc||INFLAMMATORY BOWEL DISEASE 19; IBD19|
|Desc||PSORIASIS SUSCEPTIBILITY 11; PSORS11|
|| [PMID 20570966]
|| Crohn's disease
|| Fucosyltransferase 2(FUT2) Non-Secretor Status is associated with Crohn's Disease
| Risk Allele
| Odds Ratio
|| 1.45 [1.27-1.64]
DeCode reports that rs10045431 affects susceptibility to Crohn's disease. [PMID 18587394]
[PMID 17587057] Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis.
[PMID 18438406] Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease.
[PMID 19068216] Investigation of Crohn's disease risk loci in ulcerative colitis further defines their molecular relationship.
[PMID 19468064] Parasites represent a major selective force for interleukin genes and shape the genetic predisposition to autoimmune conditions.
[PMID 19557189] Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions.
[PMID 21304977] An investigation of genome-wide studies reported susceptibility loci for ulcerative colitis shows limited replication in north Indians.
[PMID 22194214] Replication study of 10 genes showing evidence for association with multiple sclerosis: validation of TMEM39A, IL12B and CBLB [correction of CLBL] genes