rs10045431
Orientation | plus |
Stabilized | plus |
Make rs10045431(A;A) |
Make rs10045431(A;C) |
Make rs10045431(C;C) |
Reference | GRCh38 38.1/141 |
Chromosome | 5 |
Position | 159387525 |
is a | snp |
is | mentioned by |
dbSNP | rs10045431 |
dbSNP (classic) | rs10045431 |
ClinGen | rs10045431 |
ebi | rs10045431 |
HLI | rs10045431 |
Exac | rs10045431 |
Gnomad | rs10045431 |
Varsome | rs10045431 |
LitVar | rs10045431 |
Map | rs10045431 |
PheGenI | rs10045431 |
Biobank | rs10045431 |
1000 genomes | rs10045431 |
hgdp | rs10045431 |
ensembl | rs10045431 |
geneview | rs10045431 |
scholar | rs10045431 |
rs10045431 | |
pharmgkb | rs10045431 |
gwascentral | rs10045431 |
openSNP | rs10045431 |
23andMe | rs10045431 |
SNPshot | rs10045431 |
SNPdbe | rs10045431 |
MSV3d | rs10045431 |
GWAS Ctlg | rs10045431 |
GMAF | 0.1758 |
Max Magnitude | 0 |
? | (A;A) (A;C) (C;C) | 28 |
---|---|---|
|
GWAS | |
---|---|
SNP | rs10045431 |
PubMedID | [PMID 18587394] |
Condition | Crohn's disease |
Gene | IL12B |
Risk Allele | C |
pValue | 4.00E-013 |
OR | 1.11 |
95% CI |
GWAS snp | |
---|---|
PMID | [PMID 20570966] |
Trait | Crohn's disease |
Title | Fucosyltransferase 2(FUT2) Non-Secretor Status is associated with Crohn's Disease |
Risk Allele | |
P-val | 7E-8 |
Odds Ratio | 1.45 [1.27-1.64] |
DeCode reports that rs10045431 affects susceptibility to Crohn's disease. [PMID 18587394]
[PMID 17587057] Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis.
[PMID 18438406] Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease.
[PMID 19068216] Investigation of Crohn's disease risk loci in ulcerative colitis further defines their molecular relationship.
[PMID 19468064] Parasites represent a major selective force for interleukin genes and shape the genetic predisposition to autoimmune conditions.
[PMID 19557189] Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions.
[PMID 21304977] An investigation of genome-wide studies reported susceptibility loci for ulcerative colitis shows limited replication in north Indians.
[PMID 22194214] Replication study of 10 genes showing evidence for association with multiple sclerosis: validation of TMEM39A, IL12B and CBLB [correction of CLBL] genes
[PMID 33390082] The Polymorphisms of Interleukin-12B Gene and Susceptibility to Inflammatory Bowel Diseases: A Meta-analysis and Trial Sequential Analysis.