|| common in complete genomics
|?|| (C;C) (C;T) (T;T) ||28|
|Desc||INFLAMMATORY BOWEL DISEASE 19; IBD19|
|Desc||IMMUNITY-RELATED GTPase FAMILY, M; IRGM|
] Polymorphic Allele of Human IRGM1 Is Associated with Susceptibility to Tuberculosis in African Americans
blog summary of [PMID 21278745] says
- The exonic SNP c.313C>T (rs10065172) is in perfect linkage disequilibrium (r2=1.0) with a deletion polymorphism of 20 kbp mapping upstream of the IRGM gene. This deletion has been strongly associated with Crohn's disease in several European populations or those with European ancestry.
[PMID 21508684] Risk predisposition for Crohn disease: A "ménage à trois" combining IRGM allele, miRNA and xenophagy
[PMID 18985712] Autophagy gene ATG16L1 but not IRGM is associated with Crohn's disease in Canadian children.
[PMID 19165925] Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease.
[PMID 19683022] Lack of association of NKX2-3, IRGM, and ATG16L1 inflammatory bowel disease susceptibility variants with celiac disease.
[PMID 19750224] Autophagy gene variant IRGM -261T contributes to protection from tuberculosis caused by Mycobacterium tuberculosis but not by M. africanum strains.
[PMID 20106866] Independent and population-specific association of risk variants at the IRGM locus with Crohn's disease.
[PMID 22508677] Associations between genetic variants in the IRGM gene and inflammatory bowel diseases in the korean population.
[PMID 24232856] Association between Variants of the Autophagy Related Gene - IRGM and Susceptibility to Crohn's Disease and Ulcerative Colitis: A Meta-Analysis
[PMID 24247223] Genetic association and functional role of Crohn disease risk alleles involved in microbial sensing, autophagy, and endoplasmic reticulum (ER) stress
[PMID 24859836] Functional IRGM polymorphism is associated with language impairment in glioma and upregulates cytokine expressions