rs1012053

Bipolar I Disorder

Orientation

plus

Stabilized

plus

Geno	Mag	Summary
(A;A)	1.5	Normal (higher) risk of Bipolar Disorder.
(A;C)	2	0.625x reduced risk of Bipolar Disorder.
(C;C)	2.1	0.39x reduced risk of Bipolar Disorder.

Reference

GRCh38 38.1/141

Chromosome

13

Position

42079301

Gene

DGKH

is a	snp
is	mentioned by
dbSNP	rs1012053
dbSNP (classic)	rs1012053
ClinGen	rs1012053
ebi	rs1012053
HLI	rs1012053
Exac	rs1012053
Gnomad	rs1012053
Varsome	rs1012053
LitVar	rs1012053
Map	rs1012053
PheGenI	rs1012053
Biobank	rs1012053
1000 genomes	rs1012053
hgdp	rs1012053
ensembl	rs1012053
geneview	rs1012053
scholar	rs1012053
google	rs1012053
pharmgkb	rs1012053
gwascentral	rs1012053
openSNP	rs1012053
23andMe	rs1012053
SNPshot	rs1012053
SNPdbe	rs1012053
MSV3d	rs1012053
GWAS Ctlg	rs1012053

GMAF

0.2548

Max Magnitude

2.1

?	(A;A) (A;C) (C;C)	28

Bipolar disorder failed to replicate in 10.1371/journal.pone.0023473

GWAS
SNP	rs1012053
PubMedID	[PMID 17486107]
Condition	Bipolar disorder
Gene	DGKH
Risk Allele	A
pValue	2.00E-008
OR	1.59
95% CI	1.35-1.87

[PMID 21771265] Genome wide association study on bipolar disorder in the Bulgarian population

[PMID 18421293] Meta-analysis of two genome-wide association studies of bipolar disorder reveals important points of agreement.

[PMID 19416921] Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry.

[PMID 19818381] Interacting genes in lithium prophylaxis: preliminary results of an exploratory analysis on the role of DGKH and NR1D1 gene polymorphisms in 199 Sardinian bipolar patients.

[PMID 22048461] Effect of variation in diacylglycerol kinase eta (DGKH) gene on brain function in a cohort at familial risk of bipolar disorder.