||1.2x increased risk for Crohn's disease
||1.8x increased risk for Crohn's disease
|?|| (C;C) (C;T) (T;T) ||28|
rs10210302 has been reported in a large study to be associated with Crohn's disease.
The risk allele (oriented to the dbSNP entry) is (T); the odds ratio associated with heterozygotes is 1.19 (CI 1.01-1.41), and for homozygotes, 1.85 (CI 1.56-2.21). [PMID 17554300]
|Desc||INFLAMMATORY BOWEL DISEASE 10; IBD10|
[PMID 18224312] Pharmacogenetics: data, concepts and tools to improve drug discovery and drug treatment.
[PMID 18438406] Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease.
[PMID 18533027] Worldwide population differentiation at disease-associated SNPs.
[PMID 20846217] Association of linear growth impairment in pediatric Crohn's disease and a known height locus: a pilot study.
[PMID 25712183] Genetic polymorphism in ATG16L1 gene influences the response to adalimumab in Crohn's disease patients
[PMID 29228965] Genetic polymorphism in ATG16L1 gene is associated with adalimumab use in inflammatory bowel disease.