rs1044396
Orientation | minus |
Stabilized | minus |
Geno | Mag | Summary |
---|---|---|
(C;C) | 2 | Increased risk of Nicotine dependence among males |
Make rs1044396(C;T) |
Make rs1044396(T;T) |
Reference | GRCh38 38.1/142 |
Chromosome | 20 |
Position | 63349782 |
Gene | CHRNA4 |
is a | snp |
is | mentioned by |
dbSNP | rs1044396 |
dbSNP (classic) | rs1044396 |
ClinGen | rs1044396 |
ebi | rs1044396 |
HLI | rs1044396 |
Exac | rs1044396 |
Gnomad | rs1044396 |
Varsome | rs1044396 |
LitVar | rs1044396 |
Map | rs1044396 |
PheGenI | rs1044396 |
Biobank | rs1044396 |
1000 genomes | rs1044396 |
hgdp | rs1044396 |
ensembl | rs1044396 |
geneview | rs1044396 |
scholar | rs1044396 |
rs1044396 | |
pharmgkb | rs1044396 |
gwascentral | rs1044396 |
openSNP | rs1044396 |
23andMe | rs1044396 |
SNPshot | rs1044396 |
SNPdbe | rs1044396 |
MSV3d | rs1044396 |
GWAS Ctlg | rs1044396 |
GMAF | 0.3609 |
Max Magnitude | 2 |
? | (C;C) (C;T) (T;T) | 28 |
---|---|---|
|
[PMID 15154117] associated with vulnerability to nicotine addiction in men.
g2b2mh blog rs1044396 mediates effects of nicotine self-medication via parietal cortex. subjects with the (T;T) genotype showed robust brain activity in the parietal cortex while subjects with the (C;C) genotype showed very little change in activity.
OMIM | 118504 |
Desc | CHOLINERGIC RECEPTOR, NEURONAL NICOTINIC, ALPHA POLYPEPTIDE 4; CHRNA4 |
Variant | 0005 |
Related | also |
[PMID 19482438] Association of genes coding for the alpha-4, alpha-5, beta-2 and beta-3 subunits of nicotinic receptors with cigarette smoking and nicotine dependence
[PMID 22008229] Association of CHRNA4 polymorphism with depression and loneliness in elderly males
[PMID 17135278] Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs.
[PMID 17503330] A generalized combinatorial approach for detecting gene-by-gene and gene-by-environment interactions with application to nicotine dependence.
[PMID 17613539] Association of attentional network function with exon 5 variations of the CHRNA4 gene.
[PMID 17948872] Association of dopamine, serotonin, and nicotinic gene polymorphisms with methylphenidate response in ADHD.
[PMID 18534558] Gene-gene interactions among CHRNA4, CHRNB2, BDNF, and NTRK2 in nicotine dependence.
[PMID 18571741] Genetic variability in nicotinic acetylcholine receptors and nicotine addiction: converging evidence from human and animal research.
[PMID 18618000] A candidate gene approach identifies the CHRNA5-A3-B4 region as a risk factor for age-dependent nicotine addiction.
[PMID 19211801] Synergistic effects of genetic variation in nicotinic and muscarinic receptors on visual attention but not working memory.
[PMID 19238175] New insights into the genetics of addiction.
[PMID 19259974] Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes.
[PMID 19429020] Individual variation in a cholinergic receptor gene modulates attention.
[PMID 20493238] Genetic variation of CHRNA4 does not modulate attention in Parkinson's disease.
[PMID 21130611] Evidence for the modality independence of the genetic epistasis between the dopaminergic and cholinergic system on working memory capacity.
[PMID 22180580] Association Between Nicotinic Acetylcholine Receptor Single Nucleotide Polymorphisms and Smoking Cessation.
[PMID 22373960] A cognitive phenotype for a polymorphism in the nicotinic receptor gene CHRNA4.
[PMID 22722381] The role of the CHRNA4 gene in Internet addiction: a case-control study.
[PMID 22760121] Interaction of the cholinergic system and the hypothalamic-pituitary-adrenal axis as a risk factor for depression: evidence from a genetic association study.
[PMID 22947540] The dopamine D2 receptor gene DRD2 and the nicotinic acetylcholine receptor gene CHRNA4 interact on striatal gray matter volume: evidence from a genetic imaging study.
[PMID 23350800] Nominal association with CHRNA4 variants and nicotine dependence.
[PMID 25647695] Modulation of nicotine effects on selective attention by DRD2 and CHRNA4 gene polymorphisms
ClinVar | |
---|---|
Risk | rs1044396(G;G) rs1044396(T;T) |
Alt | rs1044396(G;G) rs1044396(T;T) |
Reference | Rs1044396(C;C) |
Significance | Other |
Disease | Nicotine addiction not specified |
Variation | info |
Gene | CHRNA4 |
CLNDBN | Nicotine addiction, protection against not specified |
Reversed | 1 |
HGVS | NC_000020.10:g.61981134G>A |
CLNSRC | OMIM Allelic Variant |
CLNACC | RCV000019053.2, RCV000079313.9, |