rs10484554
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | 0 | common |
| (C;T) | 2.5 | 2.8x increased risk for psoriasis |
| (T;T) | 2.5 | ~4x increased risk for psoriasis |
| Reference | GRCh38 38.1/141 |
| Chromosome | 6 |
| Position | 31306778 |
| Gene | LOC105375015, LOC107984144, LOC107984145, LOC107984146 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs10484554 |
| dbSNP (classic) | rs10484554 |
| ClinGen | rs10484554 |
| ebi | rs10484554 |
| HLI | rs10484554 |
| Exac | rs10484554 |
| Gnomad | rs10484554 |
| Varsome | rs10484554 |
| LitVar | rs10484554 |
| Map | rs10484554 |
| PheGenI | rs10484554 |
| Biobank | rs10484554 |
| 1000 genomes | rs10484554 |
| hgdp | rs10484554 |
| ensembl | rs10484554 |
| geneview | rs10484554 |
| scholar | rs10484554 |
| rs10484554 | |
| pharmgkb | rs10484554 |
| gwascentral | rs10484554 |
| openSNP | rs10484554 |
| 23andMe | rs10484554 |
| SNPshot | rs10484554 |
| SNPdbe | rs10484554 |
| MSV3d | rs10484554 |
| GWAS Ctlg | rs10484554 |
| GMAF | 0.1074 |
| Max Magnitude | 2.5 |
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
|
| ||
[PMID 18369459
] rs10484554 was the most highly significant SNP associated with risk for psoriasis in a large US/UK study.
[PMID 24270849] rs10484554 was found to be associated with psoriasis based on a study by the eMERGE network in which electronic medical records were searched to find what clinical associations were associated with selected SNPs.
| GWAS snp | |
|---|---|
| PMID | [PMID 19115949] |
| Trait | AIDS progression |
| Title | Genomewide Association Study of an AIDS-Nonprogression Cohort Emphasizes the Role Played by HLA Genes (ANRS Genomewide Association Study 02). |
| Risk Allele | T |
| P-val | 6E-8 |
| Odds Ratio | NR NR |
| GWAS snp | |
|---|---|
| PMID | [PMID 20953190]
|
| Trait | |
| Title | A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1 |
| Risk Allele | |
| P-val | 0 |
| Odds Ratio | 4.6600 [4.23-5.13] |
[PMID 19107206] Distinct genetic loci control plasma HIV-RNA and cellular HIV-DNA levels in HIV-1 infection: the ANRS Genome Wide Association 01 study.
[PMID 19182814] New insights into the pathogenesis and genetics of psoriatic arthritis.
[PMID 19569043] Genome-wide association studies and the genetic dissection of complex traits.
[PMID 21221856] The search for host genetic factors of HIV/AIDS pathogenesis in the post-genome era: progress to date and new avenues for discovery.
[PMID 21253569] Genome-wide association study SNPs in the human genome diversity project populations: does selection affect unlinked SNPs with shared trait associations?
[PMID 21304891] A study of CNVs as trait-associated polymorphisms and as expression quantitative trait loci.
[PMID 22474614] Host Genes Important to HIV Replication and Evolution.
[PMID 24566686] Human leukocyte antigen (HLA)-C polymorphisms are associated with a decreased risk of rheumatoid arthritis
[PMID 22931917] Genetic association with ERAP1 in psoriasis is confined to disease onset after puberty and not dependent on HLA-C*06.
[PMID 27073425] Candidate gene polymorphisms and risk of psoriasis: A pilot study
[PMID 33297781] HLA-Cw6 and other HLA-C alleles, as well as MICB-DT, DDX58 and TYK2 genetic variants associate with optimal response to anti-IL-17A treatment in patients with psoriasis.
