||increased risk for smoking, nicotine dependence
rs10485057 is a SNP in the opioid receptor, mu 1 OPRM1 gene.
A study of 688 Caucasian smokers (and non-smoking controls) indicated that the rare rs10485057(G) allele was associated with higher likelihood of smoking initiation and nicotine dependence. [PMID 16887046]
[PMID 24766998] Effect of OPRM1 and stressful life events on symptoms of major depression in African American adolescents
[PMID 26042510] Association between Opioid Receptor mu 1 (OPRM1) Gene Polymorphisms and Tobacco and Alcohol Consumption in a Spanish Population