| Geno
|
Mag
|
Summary
|
| (A;A)
|
0
|
common/normal
|
| (A;G)
|
1.7
|
For Caucasians (only), likely higher respiratory failure odds among COVID-19 patients
|
| (G;G)
|
3
|
For Caucasians (only), likely higher respiratory failure odds among COVID-19 patients
|
This SNP is primarily of interest as a proxy (i.e. substitute) for rs11385942, a SNP reported in an 2020 study to be associated with higher susceptibility to respiratory failure among COVID-19 patients. The minor allele of both SNPs is associated with somewhat higher risk; see rs11385942 for details.
Note that rs10490770 is defined in dbSNP on the reverse (minus) strand. Therefore, as reported in the raw data from direct-to-consumer genotyping companies such as Ancestry or MyHeritage, the major/common ("good") allele for rs10490770 is 'T', and the minor/risk allele is 'C'. In SNPedia, those alleles are reported in accordance with the original orientation in dbSNP, and are therefore 'A' and 'G', respectively.
