rs10515860

Orientation

plus

Stabilized

plus

Geno	Mag	Summary
(G;G)	0	common in complete genomics

Make rs10515860(A;A)

Make rs10515860(A;G)

Reference

GRCh38 38.1/141

Chromosome

5

Position

163490702

Gene	HMMR, HMMR-AS1

is a	snp
is	mentioned by
dbSNP	rs10515860
dbSNP (classic)	rs10515860
ClinGen	rs10515860
ebi	rs10515860
HLI	rs10515860
Exac	rs10515860
Gnomad	rs10515860
Varsome	rs10515860
LitVar	rs10515860
Map	rs10515860
PheGenI	rs10515860
Biobank	rs10515860
1000 genomes	rs10515860
hgdp	rs10515860
ensembl	rs10515860
geneview	rs10515860
scholar	rs10515860
google	rs10515860
pharmgkb	rs10515860
gwascentral	rs10515860
openSNP	rs10515860
23andMe	rs10515860
SNPshot	rs10515860
SNPdbe	rs10515860
MSV3d	rs10515860
GWAS Ctlg	rs10515860

GMAF

0.07071

Max Magnitude

0

?	(A;A) (A;G) (G;G)	28

cancergenetics The risk of breast cancer was 23% higher in women who had one copy of genetic variant (the A-C-A haplotype: rs7712023-rs299290-rs10515860), and 46% higher in women with two copies. In addition, those women were diagnosed an average of 12 months younger than women from the control group, suggesting that HMMR is linked to early-onset breast cancer.

However, a more recent, larger European case-control study found no association between rs10515860 and risk of breast cancer.[PMID 19065580]

[PMID 19064580] breast cancer

• rs10515860 [odds ratio (OR; AA/GG), 0.85; 95% confidence interval (CI), 0.65-1.12; P(trend) = 0.9],
• rs299290 [OR (CC/TT), 1.00; 95% CI, 0.87-1.15; P(trend) = 0.7],
• rs3756648 (rs7712023) [OR (TT/CC), 0.93; 95% CI, 0.84-1.02; P(trend) = 0.1],
• rs299284 [OR (TT/CC), 1.01; 95% CI, 0.76-1.35; P(trend) = 0.5], and *rs13183712 [OR (TT/GG), 1.04; 95% CI, 0.88-1.23; P(trend) = 0.6].