rs10795668
| Orientation | plus |
| Stabilized | plus |
| Make rs10795668(A;A) |
| Make rs10795668(A;G) |
| Make rs10795668(G;G) |
| Reference | GRCh38 38.1/142 |
| Chromosome | 10 |
| Position | 8659256 |
| Gene | LOC105376400 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs10795668 |
| dbSNP (classic) | rs10795668 |
| ClinGen | rs10795668 |
| ebi | rs10795668 |
| HLI | rs10795668 |
| Exac | rs10795668 |
| Gnomad | rs10795668 |
| Varsome | rs10795668 |
| LitVar | rs10795668 |
| Map | rs10795668 |
| PheGenI | rs10795668 |
| Biobank | rs10795668 |
| 1000 genomes | rs10795668 |
| hgdp | rs10795668 |
| ensembl | rs10795668 |
| geneview | rs10795668 |
| scholar | rs10795668 |
| rs10795668 | |
| pharmgkb | rs10795668 |
| gwascentral | rs10795668 |
| openSNP | rs10795668 |
| 23andMe | rs10795668 |
| SNPshot | rs10795668 |
| SNPdbe | rs10795668 |
| MSV3d | rs10795668 |
| GWAS Ctlg | rs10795668 |
| GMAF | 0.27 |
| Max Magnitude | 0 |
| ? | (A;A) (A;G) (G;G) | 28 |
|---|---|---|
|
| ||
rs10795668 is a SNP within chromosomal region 10p14. It has been reported in several publications as being associated with higher risk for colorectal cancer.
In a replication study of ~1,800 Swedish patients, the rs10795668(G) allele was specifically also shown to be associated with younger age of onset for colorectal cancer and with sporadic cases.[PMID 20648012
] Note that this conflicts with the earlier GWAS reports concluding that the risk allele is rs10795668(A).
| GWAS | |
|---|---|
| SNP | rs10795668 |
| PubMedID | [PMID 18372905] |
| Condition | Colorectal cancer |
| Gene | Intergenic |
| Risk Allele | A |
| pValue | 3.00E-013 |
| OR | 1.12 |
| 95% CI | 1.10-1.16 |
[PMID 19843678] Enrichment of Low Penetrance Susceptibility Loci in a Dutch Familial Colorectal Cancer Cohort
[PMID 20530476] Risk of Genome-Wide Association Study-Identified Genetic Variants for Colorectal Cancer in a Chinese Population
[PMID 20659471] Genetic Heterogeneity in Colorectal Cancer Associations in Americans of African vs. European Descent
[PMID 21097774] Colorectal cancer susceptibility loci on chromosome 8q23.3 and 11q23.1 as modifiers for disease expression in lynch syndrome
[PMID 21119214] Colorectal Cancer Susceptibility Loci in a Population-Based Study: Associations with Morphological Parameters
[PMID 21179028] Replication study of SNP associations for colorectal cancer in Hong Kong Chinese
[PMID 22367214] Characterization of gene-environment interactions for colorectal cancer susceptibility loci
[PMID 22363440] cis-Expression QTL Analysis of Established Colorectal Cancer Risk Variants in Colon Tumors and Adjacent Normal Tissue
[PMID 22457859] Single nucleotide polymorphisms in colorectal cancer: associations with tumor site and TNM stage
[PMID 19011631] Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer.
[PMID 20501757] Low-penetrance susceptibility variants in familial colorectal cancer.
[PMID 21071539] Generalizability and epidemiologic characterization of eleven colorectal cancer GWAS hits in multiple populations.
[PMID 21314996] Systematic search for enhancer elements and somatic allelic imbalance at seven low-penetrance colorectal cancer predisposition loci.
[PMID 21402474] GWAS-identified colorectal cancer susceptibility locus associates with disease prognosis.
[PMID 22045029] Relationship between 16 susceptibility loci and colorectal cancer phenotype in 3146 patients.
[PMID 22235025] Susceptibility genetic variants associated with early-onset colorectal cancer.
[PMID 23359760] Single-nucleotide polymorphism associations for colorectal cancer in southern chinese population
[PMID 23712746] GENETIC SUSCEPTIBILITY VARIANTS ASSOCIATED WITH COLORECTAL CANCER PROGNOSIS
[PMID 23717594] The Genetic Variant on Chromosome 10p14 Is Associated with Risk of Colorectal Cancer: Results from a Case-Control Study and a Meta-Analysis
[PMID 23875689] Colorectal Cancer-Susceptibility Single Nucleotide Polymorphisms in Korean Population
[PMID 22848671] Association of eleven common, low-penetrance colorectal cancer susceptibility genetic variants at six risk loci with clinical outcome.
[PMID 22999960] Much of the genetic risk of colorectal cancer is likely to be mediated through susceptibility to adenomas.
[PMID 23434150] Are the common genetic variants associated with colorectal cancer risk for DNA mismatch repair gene mutation carriers?
[PMID 24801760] Common colorectal cancer risk alleles contribute to the multiple colorectal adenoma phenotype, but do not influence colonic polyposis in FAP
[PMID 24875374] Variation in the Association Between Colorectal Cancer Susceptibility Loci and Colorectal Polyps by Polyp Type
| GWAS snp | |
|---|---|
| PMID | [PMID 24836286]
|
| Trait | Colorectal cancer |
| Title | Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk. |
| Risk Allele | G |
| P-val | 5E-15 |
| Odds Ratio | 1.15 [1.11-1.19] |
[PMID 24727911] Germline variation in colorectal risk Loci does not influence treatment effect or survival in metastatic colorectal cancer
[PMID 32453900] Associations between lncRNA-related polymorphisms and hepatocellular carcinoma risk: A two-stage case-control study.
