|Associated with Chemerin Plasma Levels|
||common in complete genomics
|?|| (A;A) (A;G) (G;G) ||28|
rs10988802 is a SNP located in the PTCH1 gene. This gene is a member of the patched gene family and a receptor for sonic hedgehog. This gene functions as a tumor suppressor and has a role during embryonic development. Other SNPs in this gene have been associated with various cancers.
rs10988802 was strongly associated with plasma chemerin levels in a genome-wide association study involving 525 patients from the San Antonio Family Heart Study Cohort, originally described here [PMID 20237162].
Chemerin, also known as retinoic acid receptor responder protein 2 is thought to promote angiogenesis within expanding adipose tissue.