Have questions? Visit https://www.reddit.com/r/SNPedia

rs11045818

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(G;G) 0 common in clinvar
Make rs11045818(A;A)
Make rs11045818(A;G)
ReferenceGRCh38.p2 38.2/144
Chromosome12
Position21176827
GeneSLCO1B1
is asnp
is mentioned by
dbSNPrs11045818
dbSNP (classic)rs11045818
ClinGenrs11045818
ebirs11045818
HLIrs11045818
Exacrs11045818
Gnomadrs11045818
Varsomers11045818
LitVarrs11045818
Maprs11045818
PheGenIrs11045818
Biobankrs11045818
1000 genomesrs11045818
hgdprs11045818
ensemblrs11045818
geneviewrs11045818
scholarrs11045818
googlers11045818
pharmgkbrs11045818
gwascentralrs11045818
openSNPrs11045818
23andMers11045818
SNPshotrs11045818
SNPdbers11045818
MSV3drs11045818
GWAS Ctlgrs11045818
Max Magnitude0
? (A;A) (A;G) (G;G) 28


GWAS snp
PMID [PMID 19901119OA-icon.png]
Trait Methotrexate phramacokinetics (acute lymphoblastic leukemia)
Title Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects.
Risk Allele G
P-val 7E-7
Odds Ratio 9.30 [5.7-12.9] mL/min/m2 decrease


ClinVar
Risk rs11045818(A;A)
Alt rs11045818(A;A)
Reference Rs11045818(G;G)
Significance Probable-non-pathogenic
Disease Rotor syndrome
Variation info
Gene SLCO1B1
CLNDBN Rotor syndrome
Reversed 0
HGVS NC_000012.11:g.21329761G>A
CLNSRC
CLNACC RCV000310218.1,