rs11045879
Orientation | plus |
Stabilized | plus |
Geno | Mag | Summary |
---|---|---|
(T;T) | 0 | common in clinvar |
Make rs11045879(C;C) |
Make rs11045879(C;T) |
Reference | GRCh38 38.1/141 |
Chromosome | 12 |
Position | 21229685 |
Gene | SLCO1B1 |
is a | snp |
is | mentioned by |
dbSNP | rs11045879 |
dbSNP (classic) | rs11045879 |
ClinGen | rs11045879 |
ebi | rs11045879 |
HLI | rs11045879 |
Exac | rs11045879 |
Gnomad | rs11045879 |
Varsome | rs11045879 |
LitVar | rs11045879 |
Map | rs11045879 |
PheGenI | rs11045879 |
Biobank | rs11045879 |
1000 genomes | rs11045879 |
hgdp | rs11045879 |
ensembl | rs11045879 |
geneview | rs11045879 |
scholar | rs11045879 |
rs11045879 | |
pharmgkb | rs11045879 |
gwascentral | rs11045879 |
openSNP | rs11045879 |
23andMe | rs11045879 |
SNPshot | rs11045879 |
SNPdbe | rs11045879 |
MSV3d | rs11045879 |
GWAS Ctlg | rs11045879 |
GMAF | 0.2525 |
Max Magnitude | 0 |
? | (C;C) (C;T) (T;T) | 28 |
---|---|---|
|
[PMID 19901119] Germline Genetic Variation in an Organic Anion Transporter Polypeptide Associated With Methotrexate Pharmacokinetics and Clinical Effects
[PMID 21387541] Polymorphisms of the SLCO1B1 gene predict methotrexate-related toxicity in childhood acute lymphoblastic leukemia
[PMID 19419973] Common variants in the SLCO1B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemia.
GWAS snp | |
---|---|
PMID | [PMID 23281178] |
Trait | Metabolite levels |
Title | A genome-wide assessment of variability in human serum metabolism. |
Risk Allele | C |
P-val | 5E-15 |
Odds Ratio | NR NR |
[PMID 23222202] Polymorphisms in the methotrexate transport pathway: a new tool for MTX plasma level prediction in pediatric acute lymphoblastic leukemia.
[PMID 25098908] Influence of the folate pathway and transporter polymorphisms on methotrexate treatment outcome in osteosarcoma
ClinVar | |
---|---|
Risk | rs11045879(C;C) |
Alt | rs11045879(C;C) |
Reference | Rs11045879(T;T) |
Significance | Drug-response |
Disease | Methotrexate response - Toxicity/ADR |
Variation | info |
Gene | SLCO1B1 |
CLNDBN | methotrexate response - Toxicity/ADR |
Reversed | 0 |
HGVS | NC_000012.11:g.21382619T>C |
CLNSRC | |
CLNACC | RCV000417177.1, |
[PMID 31292326] Polymorphism in Organic Anion-Transporting Polypeptide Gene Related to Methotrexate Response in Rheumatoid Arthritis Treatment.