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rs11045879

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(T;T) 0 common in clinvar
Make rs11045879(C;C)
Make rs11045879(C;T)
ReferenceGRCh38 38.1/141
Chromosome12
Position21229685
GeneSLCO1B1
is asnp
is mentioned by
dbSNPrs11045879
dbSNP (classic)rs11045879
ClinGenrs11045879
ebirs11045879
HLIrs11045879
Exacrs11045879
Gnomadrs11045879
Varsomers11045879
LitVarrs11045879
Maprs11045879
PheGenIrs11045879
Biobankrs11045879
1000 genomesrs11045879
hgdprs11045879
ensemblrs11045879
geneviewrs11045879
scholarrs11045879
googlers11045879
pharmgkbrs11045879
gwascentralrs11045879
openSNPrs11045879
23andMers11045879
SNPshotrs11045879
SNPdbers11045879
MSV3drs11045879
GWAS Ctlgrs11045879
GMAF0.2525
Max Magnitude0
? (C;C) (C;T) (T;T) 28


[PMID 19901119OA-icon.png] Germline Genetic Variation in an Organic Anion Transporter Polypeptide Associated With Methotrexate Pharmacokinetics and Clinical Effects


[PMID 21387541] Polymorphisms of the SLCO1B1 gene predict methotrexate-related toxicity in childhood acute lymphoblastic leukemia

[PMID 19419973OA-icon.png] Common variants in the SLCO1B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemia.

GWAS snp
PMID [PMID 23281178]
Trait Metabolite levels
Title A genome-wide assessment of variability in human serum metabolism.
Risk Allele C
P-val 5E-15
Odds Ratio NR NR


[PMID 23222202] Polymorphisms in the methotrexate transport pathway: a new tool for MTX plasma level prediction in pediatric acute lymphoblastic leukemia.


[PMID 25098908] Influence of the folate pathway and transporter polymorphisms on methotrexate treatment outcome in osteosarcoma


ClinVar
Risk rs11045879(C;C)
Alt rs11045879(C;C)
Reference Rs11045879(T;T)
Significance Drug-response
Disease Methotrexate response - Toxicity/ADR
Variation info
Gene SLCO1B1
CLNDBN methotrexate response - Toxicity/ADR
Reversed 0
HGVS NC_000012.11:g.21382619T>C
CLNSRC
CLNACC RCV000417177.1,



[PMID 31292326] Polymorphism in Organic Anion-Transporting Polypeptide Gene Related to Methotrexate Response in Rheumatoid Arthritis Treatment.