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rs11212617

From SNPedia

influences Metformin response
Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 0 normal response to Metformin
(A;C) 1.5 Somewhat increased likelihood of treatment success with metformin
(C;C) 1.5 Somewhat increased likelihood of treatment success with metformin
ReferenceGRCh38 38.1/141
Chromosome11
Position108412434
GeneC11orf65
is asnp
is mentioned by
dbSNPrs11212617
dbSNP (classic)rs11212617
ClinGenrs11212617
ebirs11212617
HLIrs11212617
Exacrs11212617
Gnomadrs11212617
Varsomers11212617
LitVarrs11212617
Maprs11212617
PheGenIrs11212617
Biobankrs11212617
1000 genomesrs11212617
hgdprs11212617
ensemblrs11212617
geneviewrs11212617
scholarrs11212617
googlers11212617
pharmgkbrs11212617
gwascentralrs11212617
openSNPrs11212617
23andMers11212617
SNPshotrs11212617
SNPdbers11212617
MSV3drs11212617
GWAS Ctlgrs11212617
GMAF0.4706
Max Magnitude1.5
? (A;A) (A;C) (C;C) 28


CPMC Logo.png

This SNP has been recognized by the Coriell Personalized Medicine Collaborative ICOB.
Additional information is available here

Influences Metformin response

GWAS snp
PMID [PMID 21186350OA-icon.png]
Trait
Title Common variants neat ATM are associated with glycemic response to metformin in type 2 diabetes
Risk Allele C
P-val 3E-9
Odds Ratio 1.3500 [1.22-1.49]
GWAS snp
PMID [PMID 21845381]
Trait
Title Does metformin work for everyone? A genome-wide association study for metformin response.
Risk Allele A
P-val 3E-9
Odds Ratio None None


[PMID 22453232OA-icon.png] A gene variant near ATM is significantly associated with metformin treatment response in type 2 diabetes: a replication and meta-analysis of five cohorts.


[PMID 23171036] Metformin: a cheap and well-tolerated drug that provides benefits for viral infections


[PMID 22751958OA-icon.png] The C allele of ATM rs11212617 does not associate with metformin response in the Diabetes Prevention Program.


ClinVar
Risk Rs11212617(A;A)
Alt Rs11212617(A;A)
Reference Rs11212617(C;C)
Significance Drug-response
Disease metformin response - Efficacy
Variation info
Gene C11orf65
CLNDBN metformin response - Efficacy
Reversed 0
HGVS NC_000011.9:g.108283161C>A
CLNSRC PharmGKB Clinical Annotation
CLNACC RCV000211248.1,