rs11212617
From SNPedia
influences Metformin response |
Orientation | plus |
Stabilized | plus |
Geno | Mag | Summary |
---|---|---|
(A;A) | 0 | normal response to Metformin |
(A;C) | 1.5 | Somewhat increased likelihood of treatment success with metformin |
(C;C) | 1.5 | Somewhat increased likelihood of treatment success with metformin |
Reference | GRCh38 38.1/141 |
Chromosome | 11 |
Position | 108412434 |
Gene | C11orf65 |
is a | snp |
is | mentioned by |
dbSNP | rs11212617 |
dbSNP (classic) | rs11212617 |
ClinGen | rs11212617 |
ebi | rs11212617 |
HLI | rs11212617 |
Exac | rs11212617 |
Gnomad | rs11212617 |
Varsome | rs11212617 |
LitVar | rs11212617 |
Map | rs11212617 |
PheGenI | rs11212617 |
Biobank | rs11212617 |
1000 genomes | rs11212617 |
hgdp | rs11212617 |
ensembl | rs11212617 |
geneview | rs11212617 |
scholar | rs11212617 |
rs11212617 | |
pharmgkb | rs11212617 |
gwascentral | rs11212617 |
openSNP | rs11212617 |
23andMe | rs11212617 |
SNPshot | rs11212617 |
SNPdbe | rs11212617 |
MSV3d | rs11212617 |
GWAS Ctlg | rs11212617 |
GMAF | 0.4706 |
Max Magnitude | 1.5 |
? | (A;A) (A;C) (C;C) | 28 |
---|---|---|
|
This SNP has been recognized by the Coriell Personalized Medicine Collaborative ICOB.
|
Influences Metformin response
GWAS snp | |
---|---|
PMID | [PMID 21186350] |
Trait | |
Title | Common variants neat ATM are associated with glycemic response to metformin in type 2 diabetes |
Risk Allele | C |
P-val | 3E-9 |
Odds Ratio | 1.3500 [1.22-1.49] |
GWAS snp | |
---|---|
PMID | [PMID 21845381] |
Trait | |
Title | Does metformin work for everyone? A genome-wide association study for metformin response. |
Risk Allele | A |
P-val | 3E-9 |
Odds Ratio | None None |
[PMID 22453232] A gene variant near ATM is significantly associated with metformin treatment response in type 2 diabetes: a replication and meta-analysis of five cohorts.
[PMID 23171036] Metformin: a cheap and well-tolerated drug that provides benefits for viral infections
[PMID 22751958] The C allele of ATM rs11212617 does not associate with metformin response in the Diabetes Prevention Program.
ClinVar | |
---|---|
Risk | Rs11212617(A;A) |
Alt | Rs11212617(A;A) |
Reference | Rs11212617(C;C) |
Significance | Drug-response |
Disease | metformin response - Efficacy |
Variation | info |
Gene | C11orf65 |
CLNDBN | metformin response - Efficacy |
Reversed | 0 |
HGVS | NC_000011.9:g.108283161C>A |
CLNSRC | PharmGKB Clinical Annotation |
CLNACC | RCV000211248.1, |