|(C;T)||may require more methadone during heroin withdrawal|
|(T;T)||0||likely to require more methadone during heroin withdrawal|
A study of 98 methadone-maintaining patients concluded that the higher (>150 mg/day) and lower (< or =150 mg/day) methadone dose groups differed significantly in their rs1128503 status (experiment-wise p = 0.0325). Furthermore, individuals with the 3-locus genotype pattern (T;T)-(T;T)-(T;T) for SNPs rs1045642, rs2032582 and rs1128503, respectively, had an approximately 5-fold chance of requiring the 'higher' methadone dose, while individuals heterozygous for these three SNPs have an approximately 3-fold chance of stabilizing at the 'lower' methadone dose (point-wise p-value = 0.026).[PMID 18424454]
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[PMID 22569204] PharmGKB summary: phenytoin pathway.
[PMID 23188198] ABCB1 polymorphism predicts escitalopram dose needed for remission in major depression
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[PMID 23786015] [Pharmacogenetic criteria drug-resistence epilepsy]
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