rs11465804
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (G;G) | 1.5 | 0.68x lower risk for spondylitis |
| (G;T) | 1.5 | 0.68x lower risk for spondylitis |
| (T;T) | 0 | normal risk |
| Reference | GRCh38 38.1/141 |
| Chromosome | 1 |
| Position | 67236843 |
| Gene | IL23R |
| is a | snp |
| is | mentioned by |
| dbSNP | rs11465804 |
| dbSNP (classic) | rs11465804 |
| ClinGen | rs11465804 |
| ebi | rs11465804 |
| HLI | rs11465804 |
| Exac | rs11465804 |
| Gnomad | rs11465804 |
| Varsome | rs11465804 |
| LitVar | rs11465804 |
| Map | rs11465804 |
| PheGenI | rs11465804 |
| Biobank | rs11465804 |
| 1000 genomes | rs11465804 |
| hgdp | rs11465804 |
| ensembl | rs11465804 |
| geneview | rs11465804 |
| scholar | rs11465804 |
| rs11465804 | |
| pharmgkb | rs11465804 |
| gwascentral | rs11465804 |
| openSNP | rs11465804 |
| 23andMe | rs11465804 |
| SNPshot | rs11465804 |
| SNPdbe | rs11465804 |
| MSV3d | rs11465804 |
| GWAS Ctlg | rs11465804 |
| GMAF | 0.03903 |
| Max Magnitude | 1.5 |
| ? | (G;G) (G;T) (T;T) | 28 |
|---|---|---|
|
| ||
rs11465804 is one of several SNPs in the IL23R gene that has been shown in a large (over 1,000 Caucasian patients) study to be associated with ankylosing spondylitis. The odds ratio is 0.68 (p=0.0002).[PMID 17952073, PMID 18037607]
| GWAS | |
|---|---|
| SNP | rs11465804 |
| PubMedID | [PMID 17804789 ]
|
| Condition | Crohn's disease |
| Gene | IL23R |
| Risk Allele | |
| pValue | 1.00E-008 |
| OR | 1.38 |
| 95% CI | 1.23-1.53 |
| GWAS snp | |
|---|---|
| PMID | [PMID 18587394]
|
| Trait | Crohn's disease |
| Title | Genome-wide assocation defines more than 30 distinct susceptibility loci for Crohn's disease |
| Risk Allele | T |
| P-val | 7.0000000000000001E-63 |
| Odds Ratio | 2.50 [NR] |
| GWAS snp | |
|---|---|
| PMID | [PMID 20570966]
|
| Trait | Crohn's disease |
| Title | Fucosyltransferase 2(FUT2) Non-Secretor Status is associated with Crohn's Disease |
| Risk Allele | |
| P-val | 0.000001 |
| Odds Ratio | 1.89 [1.47-2.44] |
[PMID 22089529] Associations between interleukin-23R polymorphisms and ankylosing spondylitis susceptibility: a meta-analysis
[PMID 22269043] Clinical predictors of inflammatory bowel disease in a genetically well-defined Caucasian population
[PMID 22440928] Perianal Crohn's Disease: Predictive Factors and Genotype-Phenotype Correlations
[PMID 17068223] A genome-wide association study identifies IL23R as an inflammatory bowel disease gene.
[PMID 17447842] Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4.
[PMID 17786191] rs1004819 is the main disease-associated IL23R variant in German Crohn's disease patients: combined analysis of IL23R, CARD15, and OCTN1/2 variants.
[PMID 18047539] Association between genetic variants in the IL-23R gene and early-onset Crohn's disease: results from a case-control and family-based study among Canadian children.
[PMID 18369459] A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci.
[PMID 18383363] Association of interleukin-23 receptor variants with ankylosing spondylitis.
[PMID 18758464] Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease.
[PMID 19122664] Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study.
[PMID 19175939] IL23R in the Swedish, Finnish, Hungarian and Italian populations: association with IBD and psoriasis, and linkage to celiac disease.
[PMID 19189980] Association between the interleukin 23 receptor and ankylosing spondylitis is confirmed by a new UK case-control study and meta-analysis of published series.
[PMID 19408013] Strategies and issues in the detection of pathway enrichment in genome-wide association studies.
[PMID 19468064] Parasites represent a major selective force for interleukin genes and shape the genetic predisposition to autoimmune conditions.
[PMID 19557189] Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions.
[PMID 19918037] Association of interleukin 23 receptor polymorphisms with anti-topoisomerase-I positivity and pulmonary hypertension in systemic sclerosis.
[PMID 20018022] Replication of recently identified associated single-nucleotide polymorphisms from six autoimmune diseases in Genetic Analysis Workshop 16 rheumatoid arthritis data.
[PMID 20454450] Evidence for STAT4 as a common autoimmune gene: rs7574865 is associated with colonic Crohn's disease and early disease onset.
[PMID 21304977] An investigation of genome-wide studies reported susceptibility loci for ulcerative colitis shows limited replication in north Indians.
[PMID 23725363] Predicting complicated Crohn's disease and surgery: phenotypes, genetics, serology and psychological characteristics of a population-based cohort.
[PMID 24998354] Determination of IL-23 receptor gene polymorphism in Iranian patients with ankylosing spondylitis
[PMID 29228965] Genetic polymorphism in ATG16L1 gene is associated with adalimumab use in inflammatory bowel disease.
[PMID 31615448] Candidate single nucleotide polymorphisms of irritable bowel syndrome: a systemic review and meta-analysis.
