rs1154155

Orientation

plus

Stabilized

plus

Geno	Mag	Summary
(G;G)	2.5	2.5x increased risk for narcolepsy
(G;T)	1.5	1.94x increased risk for narcolepsy
(T;T)	0	normal

Reference

GRCh38 38.1/141

Chromosome

14

Position

22533736

Gene

TRA

is a	snp
is	mentioned by
dbSNP	rs1154155
dbSNP (classic)	rs1154155
ClinGen	rs1154155
ebi	rs1154155
HLI	rs1154155
Exac	rs1154155
Gnomad	rs1154155
Varsome	rs1154155
LitVar	rs1154155
Map	rs1154155
PheGenI	rs1154155
Biobank	rs1154155
1000 genomes	rs1154155
hgdp	rs1154155
ensembl	rs1154155
geneview	rs1154155
scholar	rs1154155
google	rs1154155
pharmgkb	rs1154155
gwascentral	rs1154155
openSNP	rs1154155
23andMe	rs1154155
SNPshot	rs1154155
SNPdbe	rs1154155
MSV3d	rs1154155
GWAS Ctlg	rs1154155

GMAF

0.2365

Max Magnitude

2.5

?	(G;G) (G;T) (T;T)	28

rs1154155 is a SNP in the TCRA T-cell receptor alpha gene. The minor allele is (G).

A study of 1,830 people with narcolepsy and cataplexy (a sudden loss of muscle tone that can cause people to collapse) compared to 2,164 healthy controls concluded that several SNPs in the TCRA gene were linked. The most significant association was with this SNP, rs1154155, with an average allelic odds ratio of 1.69 (genotypic odds ratios 1.94 and 2.55, p < 10e-21).[PMID 19412176]

Note the following, though, as quoted from a Science News article: "Even with all of the known genetic risk factors, including the newly discovered version of the T cell receptor gene, a person has only a 1.5 percent chance of developing narcolepsy.... That suggests that, while narcolepsy is probably an autoimmune disorder, further genetic and environmental triggers and risk factors remain to be found."

HLA-DQB1*0602 and relevance to Narcolepsy related to vaccination

A study of 500+ Chinese patients with narcolepsy confirms that narcolepsy is strongly and dose dependently associated with rs1154155(G) in this population.[PMID 22177342]

[PMID 19927159] Polymorphism located in TCRA locus confers susceptibility to essential hypersomnia with HLA-DRB1*1501-DQB1*0602 haplotype

GWAS snp
PMID	[PMID 20711174]
Trait
Title	Genome-wide association study identifies new HLA class II haplotypes strongly protective against narcolepsy
Risk Allele	G
P-val	5E-7
Odds Ratio	1.54 [1.30-1.95]

OMIM	612851
Desc
Variant
Related	also

GWAS snp
PMID	[PMID 24204295]
Trait	Narcolepsy
Title	Genome wide analysis of narcolepsy in China implicates novel immune loci and reveals changes in association prior to versus after the 2009 H1N1 influenza pandemic.
Risk Allele	G
P-val	5E-49
Odds Ratio	1.64 [1.53-1.75]

[PMID 24381371] DQB1 locus alone explains most of the risk and protection in narcolepsy with cataplexy in Europe