||At least 2x higher risk for vitamin D insufficiency; also somewhat higher risk for MS
||~2x higher risk for vitamin D insufficiency; also 1.4x higher risk for MS
rs117913124 represents a synonymous variant (p.Aps120Asp) in the CYP2R1 gene on chromosome 11.
Sequencing, imputation and meta-analysis led to the conclusion that the rs117913124(A) minor allele leads to ~2x the risk of Vitamin D insufficiency, defined as 25OHD levels < 50nmol/L (odds ratio 2.2, CI:1.8-2.8, p = 1.2x10e12). Individuals carrying a rs117913124(A) allele also had somewhat higher odds of developing multiple sclerosis (OR 1.4, CI: 1.19-1.64, p = 2.63x10e-5).[PMID 28757204]