| Geno
|
Mag
|
Summary
|
| (A;A)
|
1.8
|
common but +17% risk Osteoarthritis
|
| (A;G)
|
1.2
|
+17% increased risk for osteoarthritis
|
| (G;G)
|
1.4
|
reduced risk for osteoarthritis
|
rs11842874 is a SNP in the MCF.2 cell line derived transforming sequence-like MCF2L gene on ch 13.
Based initially on a GWAS study of 3,000 patients of European ancestry with osteoarthritis and then subsequently replicated for a total of 19,000+ cases, the rs11842874(A) allele (major allele) was associated with increased risk, at an odds ratio of 1.17 (CI: 1.11–1.23, p = 2.1 × 10e?8). The authors note that MCF2L regulates a nerve growth factor (NGF), and treatment with a humanized monoclonal antibody against NGF is associated with reduction in pain and improvement in function for knee osteoarthritis patients.10.1016/j.ajhg.2011.08.001
| GWAS snp
|
| PMID
|
[PMID 21871595 ]
|
| Trait
|
|
| Title
|
A variant in MCF2L is associated with osteoarthritis.
|
| Risk Allele
|
A
|
| P-val
|
2E-8
|
| Odds Ratio
|
1.1700 [1.11-1.23]
|
[PMID 22615457] Genetic contribution to radiographic severity in osteoarthritis of the knee.
[PMID 26584642] Expression analysis of the osteoarthritis genetic susceptibility locus mapping to an intron of the MCF2L gene and marked by the polymorphism rs11842874
]
