||Normal risk of developing restless legs syndrome
||Slightly increased risk of developing restless legs syndrome
||Increased risk of developing restless legs syndrome
rs12469063, a SNP located in the MEIS1 gene, has been linked to restless legs syndrome, a common sleep disorder, with an overall odds ratio of 1.78 (CI: 1.52-2.10) for the (G) risk allele. [PMID 17637780]
The association from this region that gives the highest association to restless legs syndrome, however, is a haplotype consisting of the rs6710341(A) and rs12469063(G) alleles. This haplotype gives rise to an odds ratio of 2.75 (CI: 2.23-3.41). [PMID 17637780]
[PMID 19223043] Exploring the genetic link between RLS and ADHD
[PMID 19126776] MEIS1 intronic risk haplotype associated with restless legs syndrome affects its mRNA and protein expression levels.
[PMID 19279021] Replication of restless legs syndrome loci in three European populations.
[PMID 20396431] Genotyping sleep disorders patients.
[PMID 25142570] Periodic leg movements during sleep are associated with polymorphisms in BTBD9, TOX3/BC034767, MEIS1, MAP2K5/SKOR1, and PTPRD