||1.25 increased risk for gout
||normal reduced risk of gout
[PMID 23263486] Each copy of the minor (G) allele appears to confer reduced risk for gout based on combined data from over 140,000 individuals of European ancestry within the Global Urate Genetics Consortium (GUGC), replicating an association reported earlier for a linked SNP in this gene.
||Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.
||.37 [0.36-0.38] mg/dl increase
[PMID 19503597] Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations.
[PMID 32292418] Serum Uric Acid Level and Multiple Sclerosis: A Mendelian Randomization Study.