| Geno
|
Mag
|
Summary
|
| (A;A)
|
1.36
|
slight increase in risk for migraine
|
| (A;G)
|
1.18
|
slight increase in risk for migraine
|
| (G;G)
|
0
|
common/normal
|
rs13208321 represents a SNP located in chromosomal region 6q16, potentiallly within the FHL5 gene. The FHL5 gene encodes a transcription factor that regulates cAMP responsive elements CREM and CREB6, which play a role in synaptic plasticity and memory formation. However, it is not known if this is associated in any way with the migraine risk associated with this SNP.
[PMID 23793025
] A meta-analysis across 29 GWA studies, including a total of 23,285 migraine cases and 95,425 population-matched controls, found a slight increase in risk for migraine associated with rs13208321(A), (OR 1.18, CI:1.13-1.24, p=2.15 × 10e-12).
[PMID 26231841] Association of genetic loci for migraine susceptibility in the she people of China
] A meta-analysis across 29 GWA studies, including a total of 23,285 migraine cases and 95,425 population-matched controls, found a slight increase in risk for migraine associated with rs13208321(A), (OR 1.18, CI:1.13-1.24, p=2.15 × 10e-12).
