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rs1406844918

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;T) 4.9 Short sleeper; rare mutation reported to reduce sleep time needed
(T;T) 0 common/normal; 8+ hours of sleep typically needed


Make rs1406844918(C;C)
is asnp
is mentioned by
dbSNPrs1406844918
dbSNP (classic)rs1406844918
ClinGenrs1406844918
ebirs1406844918
HLIrs1406844918
Exacrs1406844918
Gnomadrs1406844918
Varsomers1406844918
LitVarrs1406844918
Maprs1406844918
PheGenIrs1406844918
Biobankrs1406844918
1000 genomesrs1406844918
hgdprs1406844918
ensemblrs1406844918
geneviewrs1406844918
scholarrs1406844918
googlers1406844918
pharmgkbrs1406844918
gwascentralrs1406844918
openSNPrs1406844918
23andMers1406844918
SNPshotrs1406844918
SNPdbers1406844918
MSV3drs1406844918
GWAS Ctlgrs1406844918
Max Magnitude4.9

rs1406844918 represents a rare mutation known as the Y206H (p.Tyr206His) mutation in the neuropeptide S receptor 1 NPSR1 gene, located on chromosome 7.

In 2019, a report was published indicating this mutation was responsible for the short sleep phenotype observed in a (single) Chinese family. It is apparently a gain-of-function mutation and thus able to be inherited in a dominant manner. People with this trait [familial natural short sleep (FNSS)] have a lifelong tendency to sleep only 4 to 6 hours per night while still feeling sufficiently rested.[PMID 31619542OA-icon.png]