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rs142787485

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 0 common/normal
(A;G) 4 Possibly lower odds (~0.65x) of developing Alzheimer's in individuals at higher risk for the disorder
(G;G) 4 Possibly lower odds (~0.65x) of developing Alzheimer's in individuals at higher risk for the disorder
ReferenceGRCh38.p2 38.2/147
Chromosome2
Position26135287
GeneRAB10
is asnp
is mentioned by
dbSNPrs142787485
dbSNP (old)rs142787485
ClinGenrs142787485
ebirs142787485
HLIrs142787485
Exacrs142787485
Gnomadrs142787485
Varsomers142787485
Maprs142787485
PheGenIrs142787485
Biobankrs142787485
1000 genomesrs142787485
hgdprs142787485
ensemblrs142787485
gopubmedrs142787485
geneviewrs142787485
scholarrs142787485
googlers142787485
pharmgkbrs142787485
gwascentralrs142787485
openSNPrs142787485
23andMers142787485
23andMe allrs142787485
SNPshotrs142787485
SNPdbers142787485
MSV3drs142787485
GWAS Ctlgrs142787485
Max Magnitude4

rs142787485 represents a rare variant in the RAB10 gene on chromosome 2.

A 2017 publication reports that the rs142787485(G) allele may be associated with a lower odds of developing Alzheimer's disease in individuals otherwise at higher risk for the disorder. In ~400 individuals from the ADNI cohort tested, the rs142787485(G) allele carriers had an odds ratio of 0.58 (p value = 0.018) compared to non-carriers; in ~500 individuals from the CCS cohort tested, rs142787485(G) carriers had an odds ratio of 0.69 (CI:0.47–0.99; p value 0.028). Another SNP, rs7653, showed a similar protective effect but did not replicate in a second population tested.[PMID 29183403OA-icon.png]

The 2017 publication describes the same research cited in a report from ICAD 2016 (page 4 and page 9 of this pdf.