rs145946881

plus

Geno	Mag	Summary
(C;C)	0	common genotype

Make rs145946881(C;G)

Make rs145946881(G;G)

Reference

GRCh38 38.1/141

Chromosome

2

Position

135851176

Gene

MCM6

is a	snp
is	mentioned by
dbSNP	rs145946881
dbSNP (classic)	rs145946881
ClinGen	rs145946881
ebi	rs145946881
HLI	rs145946881
Exac	rs145946881
Gnomad	rs145946881
Varsome	rs145946881
LitVar	rs145946881
Map	rs145946881
PheGenI	rs145946881
Biobank	rs145946881
1000 genomes	rs145946881
hgdp	rs145946881
ensembl	rs145946881
geneview	rs145946881
scholar	rs145946881
google	rs145946881
pharmgkb	rs145946881
gwascentral	rs145946881
openSNP	rs145946881
23andMe	rs145946881
SNPshot	rs145946881
SNPdbe	rs145946881
MSV3d	rs145946881
GWAS Ctlg	rs145946881

Max Magnitude

0

SNPs found in the introns of the MCM6 gene which turn out to have some control over the lactase LCT gene located many thousands of base pairs away include rs145946881, known as "G/C-14010", which appears to be associated with lactase persistence in sub-Saharan African populations. Two other nearby SNPs, rs41380347 "T/G(-13915)" and rs41525747 "C/G(-13907)", are also associated to a lesser degree. [PMID 17159977, PMID 23029545]

ClinVar
Risk	rs145946881(G;G) rs145946881(T;T)
Alt	rs145946881(G;G) rs145946881(T;T)
Reference	Rs145946881(C;C)
Significance	Other
Disease	Lactase persistence
Variation	info
Gene	MCM6
CLNDBN	Lactase persistence
Reversed	0
HGVS	NC_000002.11:g.136608746C>G
CLNSRC	OMIM Allelic Variant
CLNACC	RCV000008126.2,

[PMID 29063188 ] World-wide distributions of lactase persistence alleles and the complex effects of recombination and selection.