rs1470579

plus

Geno	Mag	Summary
(A;A)	0	normal
(A;C)		1.2x increased risk for type-2 diabetes
(C;C)		1.2x increased risk for type-2 diabetes

Reference

GRCh38 38.1/141

Chromosome

3

Position

185811292

Gene

IGF2BP2

is a	snp
is	mentioned by
dbSNP	rs1470579
dbSNP (classic)	rs1470579
ClinGen	rs1470579
ebi	rs1470579
HLI	rs1470579
Exac	rs1470579
Gnomad	rs1470579
Varsome	rs1470579
LitVar	rs1470579
Map	rs1470579
PheGenI	rs1470579
Biobank	rs1470579
1000 genomes	rs1470579
hgdp	rs1470579
ensembl	rs1470579
geneview	rs1470579
scholar	rs1470579
google	rs1470579
pharmgkb	rs1470579
gwascentral	rs1470579
openSNP	rs1470579
23andMe	rs1470579
SNPshot	rs1470579
SNPdbe	rs1470579
MSV3d	rs1470579
GWAS Ctlg	rs1470579

GMAF

0.4123

Max Magnitude

0

?

(A;A) (A;C) (C;C)

28

[PMID 18477659] rs1470579 replicated as significant for type-2 diabetes risk in 1,900 Japanese patients, with odds ratio of 1.18 (CI: 1.07-1.31, p = 8.3 x 10e-4)

[PMID 18461161 ] T2D and normal glucose tolerant (NGT) individuals. (3,295 T2D and 3,595 NGT), strong associations with T2D were found for

CDKAL1 (OR(rs7756992) = 1.30[1.19-1.42], P = 2.3x10(-9))
CDKN2A/2B (OR(rs10811661) = 0.74[0.66-0.82], P = 3.5x10(-8))
IGFBP2 (OR(rs1470579) = 1.17[1.07-1.27], P = 0.0003) SNPs.

T2D risk increased strongly when risk alleles, including the previously discovered T2D-associated TCF7L2 rs7903146 SNP, were combined (8.68-fold for the 14% of French individuals carrying 18 to 30 risk alleles with an allelic OR of 1.24)

[PMID 18430866 ] Neither rs4402960 or rs1470579 were found to be associated with type-2 diabetes in a study of 3,000 French Caucasians.

[PMID 19033397 ] This SNP was confirmed to be associated with type-2 diabetes in a study of 500+ Japanese patients plus pooled meta-analysis with 6 previous association studies (also of Japanese).

Note: rs1470579 is fairly tightly linked (r2=0.87) with another IGF2BP2 gene SNP also associated with type-2 diabetes, rs4402960

GWAS snp
PMID	[PMID 17463246]
Trait	Type 2 diabetes
Title	Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
Risk Allele	C
P-val	1E-9
Odds Ratio	1.17 [1.11-1.23]

[PMID 20523342 ] IGF2BP2 variations influence repaglinide response and risk of type 2 diabetes in Chinese population

GWAS snp
PMID	[PMID 20581827 ]
Trait	Type 2 diabetes
Title	Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
Risk Allele	C
P-val	2E-9
Odds Ratio	1.14 [1.09-1.19]

GWAS snp
PMID	[PMID 22233651 ]
Trait
Title	A genome-wide association study of gestational diabetes mellitus in korean women.
Risk Allele	C
P-val	2E-7
Odds Ratio	1.3320 None

[PMID 22569928 ] Analysis of common type 2 diabetes mellitus genetic risk factors in new-onset diabetes after transplantation in kidney transplant patients medicated with tacrolimus

[PMID 18426861 ] Association analysis of type 2 diabetes Loci in type 1 diabetes.

[PMID 18544707 ] Extension of type 2 diabetes genome-wide association scan results in the diabetes prevention program.

[PMID 18633108 ] Common variants in CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, and HHEX/IDE genes are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population.

[PMID 19008344 ] Association analysis of variation in/near FTO, CDKAL1, SLC30A8, HHEX, EXT2, IGF2BP2, LOC387761, and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians.

[PMID 19020323 ] Genotype score in addition to common risk factors for prediction of type 2 diabetes.

[PMID 19096518 ] Novel association of HK1 with glycated hemoglobin in a non-diabetic population: a genome-wide evaluation of 14,618 participants in the Women's Genome Health Study.

[PMID 19956539 ] How many genetic variants remain to be discovered?

[PMID 20043853 ] Prioritizing genes for follow-up from genome wide association studies using information on gene expression in tissues relevant for type 2 diabetes mellitus.

[PMID 20144327 ] A genomics study of type 2 diabetes mellitus in U.S. Air Force personnel.

[PMID 22015911] Quantitative assessment of the variation in IGF2BP2 gene and type 2 diabetes risk.

[PMID 22245690] Strong association of common variants in the IGF2BP2 gene with type 2 diabetes in Lebanese Arabs.

[PMID 22377712] Association between type 2 diabetes genetic susceptibility loci and visceral and subcutaneous fat area as determined by computed tomography.

GWAS snp
PMID	[PMID 22581228 ]
Trait
Title	A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
Risk Allele
P-val	6E-7
Odds Ratio	None None

GWAS snp
PMID	[PMID 23300278 ]
Trait	Type 2 diabetes
Title	Genome-Wide Association Study Identifies a Novel Locus Contributing to Type 2 Diabetes Susceptibility in Sikhs of Punjabi Origin From India.
Risk Allele	C
P-val	2E-13
Odds Ratio	1.06 [1.04-1.08]

[PMID 22749234] Contribution of common variants of ENPP1, IGF2BP2, KCNJ11, MLXIPL, PPARγ, SLC30A8 and TCF7L2 to the risk of type 2 diabetes in Lebanese and Tunisian Arabs

[PMID 23462794 ] Identification of CpG-SNPs associated with type 2 diabetes and differential DNA methylation in human pancreatic islets.

GWAS snp
PMID	[PMID 23945395]
Trait	Type 2 diabetes
Title	Genome-wide association study identifies three novel loci for type 2 diabetes.
Risk Allele	C
P-val	5E-14
Odds Ratio	1.19 [1.14-1.24]