|(G;G)||~1.7x increased obesity risk|
|(G;T)||~1.3x increased obesity risk|
Within the FTO gene, many SNPs appear to be co-inherited. The SNP showing the strongest association with body weight (i.e. body mass index, BMI) is not rs17817449, although this SNP is one of co-inherited SNPs in the FTO gene region. For more information, refer to the FTO gene or the most studied of FTO SNPs, rs9930506. [PMID 17658951]
[PMID 18316358] A study of 900+ Quebec individuals reported that rs17817449 was associated with BMI (p=0.0014), weight (p=0.0059) and waist circumference (p=0.0021) under an additive model, and in addition, influenced fasting insulin (p=0.011) and HOMA-IR (p=0.038).
- Note: The three FTO SNPs, rs1421085, rs17817449, and rs9939609, are in strong linkage disequilibrium (pairwise r2>0.97), and there are two primary haplotypes, C-G-A (42.0 %) and T-T-T (55.5 %).
[PMID 19278366] A common variant in the FTO gene is associated with body mass index in males and postmenopausal females but not in premenopausal females Czech post-MONICA and 3PMFs studies.
[PMID 19322589] Analysis of FTO gene variants with measures of obesity and glucose homeostasis in the IRAS Family Study
[PMID 20717169] FTO genotype and adiposity in children: physical activity levels influence the effect of the risk genotype in adolescent males
[PMID 20945952] FTO variant, energy intake, physical activity and basal metabolic rate in Caucasians. The HAPIEE study
|Title||A genome-wide association study on obesity and obesity-related traits.|
|Odds Ratio||None None|
[PMID 20945953] Body mass index change in females after short-time life style intervention is not dependent on the FTO polymorphisms
[PMID 22030988] FTO Risk Haplotype Among Early Onset and Severe Obesity Cases in a Population of Western Spain
[PMID 17928949] FTO polymorphisms in oceanic populations.
[PMID 18218107] FTO gene SNPs associated with extreme obesity in cases, controls and extremely discordant sister pairs.
[PMID 18256137] Regulation of Fto/Ftm gene expression in mice and humans.
[PMID 18487448] Common variation in the fat mass and obesity-associated (FTO) gene confers risk of obesity and modulates BMI in the Chinese population.
[PMID 18599522] FTO variants are associated with obesity in the Chinese and Malay populations in Singapore.
[PMID 18647953] Fat mass-and obesity-associated (FTO) gene variant is associated with obesity: longitudinal analyses in two cohort studies and functional test.
[PMID 18833210] The FTO gene and obesity in a large Eastern European population sample: the HAPIEE study.
[PMID 19265514] FTO gene variation and measures of body mass in an African population.
[PMID 20080751] Long-range gene regulation links genomic type 2 diabetes and obesity risk regions to HHEX, SOX4, and IRX3.
[PMID 20362563] A FTO variant and risk of acute coronary syndrome.
[PMID 20381893] The genetics of obesity: FTO leads the way.
[PMID 20404173] A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly.
[PMID 20442772] Common SNPs in FTO gene are associated with obesity related anthropometric traits in an island population from the eastern Adriatic coast of Croatia.
[PMID 20502638] Risk of type 2 diabetes and obesity is differentially associated with variation in FTO in whites and African-Americans in the ARIC study.
[PMID 21102551] Analysis of FTO gene variants with obesity and glucose homeostasis measures in the multiethnic Insulin Resistance Atherosclerosis Study cohort.
[PMID 21283731] FTO and MC4R gene variants are associated with obesity in polycystic ovary syndrome.
[PMID 21317302] FTO polymorphisms are associated with adult body mass index (BMI) and colorectal adenomas in African-Americans.
[PMID 21318054] Rs9939609 variant of the fat mass and obesity-associated gene and trunk obesity in adolescents.
[PMID 21788373] The FTO gene polymorphism is associated with end-stage renal disease: two large independent case-control studies in a general population.
[PMID 21919686] Association of FTO rs17817449 SNP with obesity and associated physiological parameters in a north Indian population.
[PMID 22157232] Lack of an association between three tagging SNPs within the FTO gene and smoking behavior.
[PMID 22187296] Variants of the FTO gene in obese children and their impact on body composition and metabolism before and after lifestyle intervention.
[PMID 22614171] Appetite regulation genes are associated with body mass index in black South African adolescents: a genetic association study.
[PMID 23136261] Fat mass and obesity gene and cognitive decline: The Atherosclerosis Risk in Communities Study
[PMID 24106974] Association between fat mass and obesity-associated (FTO) gene and hip fracture susceptibility
|Title||Genome-wide association studies identify four ER negative-specific breast cancer risk loci.|
|Odds Ratio||1.09 [1.05-1.12]|
|Title||Large-scale genotyping identifies 41 new loci associated with breast cancer risk.|
|Odds Ratio||1.08 [1.05-1.1]|
[PMID 22503908] Association between FTO 1st intron tagging variant and telomere length in middle aged females. 3PMFs study.
[PMID 23201545] FTO and MC4R gene variants determine BMI changes in children after intensive lifestyle intervention.
[PMID 23771786] Genetic variants in the fat mass- and obesity-associated (FTO) gene are associated with alcohol dependence.
[PMID 26726774] Gender-Dependent Association of FTO Polymorphisms with Body Mass Index in Mexicans.
[PMID 27196486] FTO rs 9939609 SNP Is Associated With Adiponectin and Leptin Levels and the Risk of Obesity in a Cohort of Romanian Children Population.
[PMID 29154870] The FTO variant is associated with chronic complications of diabetes mellitus in Czech population.