rs1800795

Orientation

plus

Stabilized

plus

Geno	Mag	Summary
(C;C)	2	less IL6; certain risks, see details
(C;G)		complex; see details
(G;G)	2	more IL6; certain risks, see details

Reference

GRCh38 38.1/141

Chromosome

7

Position

22727026

Gene	IL6, LOC541472

is a	snp
is	mentioned by
dbSNP	rs1800795
dbSNP (classic)	rs1800795
ClinGen	rs1800795
ebi	rs1800795
HLI	rs1800795
Exac	rs1800795
Gnomad	rs1800795
Varsome	rs1800795
LitVar	rs1800795
Map	rs1800795
PheGenI	rs1800795
Biobank	rs1800795
1000 genomes	rs1800795
hgdp	rs1800795
ensembl	rs1800795
geneview	rs1800795
scholar	rs1800795
google	rs1800795
pharmgkb	rs1800795
gwascentral	rs1800795
openSNP	rs1800795
23andMe	rs1800795
SNPshot	rs1800795
SNPdbe	rs1800795
MSV3d	rs1800795
GWAS Ctlg	rs1800795

GMAF

0.185

Max Magnitude

2

?	(C;C) (C;G) (G;G)	28

rs1800795 is a SNP in the promoter of the interleukin-6 IL6 gene, affecting the levels made of this important cytokine. In the literature, it is almost universally referred to as the IL6 "-174" polymorphism. It tends to be quite polymorphic in Caucasians, but Asian and African populations are almost monomorphic (for the (G) allele).

It was first described in 1998, when it was shown that the rs1800795(C) allele produces less IL6 than the (G) allele, which supported the hypothesis that a protective genotype against systemic onset juvenile rheumatoid arthritis would be rs1800795(C;C), and indeed, few juvenile RA patients had that genotype.[PMID 9769329]

Studies on rs1800795 now include potential associations with heart disease, Kaposi's sarcoma, type-2 diabetes, stroke, obesity, Hodgkin's lymphoma, sudden infant death syndrome, cancer (including breast cancer, gastric cancer, prostate cancer), hypertension, periodontitis, and complications arising after organ transplantations or grafts. It is worth noting that some of the associations seen for rs1800795 alleles are not for the risk of developing a given disorder; instead, they relate to how a disorder might progress or respond to various treatments. Summaries of several major associations are available at OMIM.

The rs1800795(G) allele, generally associated with higher levels of IL6, has been associated with increased risk in the following studies:

• The rs1800795(G) allele was significantly associated with type-2 diabetes (odds ratio 1.51, CI: 1.11-2.07, p=0.0096) in a study of 700 elderly Caucasians.[PMID 15472205]

• Following a kidney transplant, patients with rs1800795(G;G) genotypes have a higher risk of new-onset diabetes and higher C-reactive protein levels) compared to the (C;C) genotype. Since this was more pronounced in overweight patients, the authors suggest that diabetes-inducing drug administration should be limited in overweight patients who are rs1800795(G;G) following renal transplantation.[PMID 16837641]

• The development of bronchiolitis obliterans syndrome (BOS) after lung transplantation is more likely and happens earlier for rs1800795(G) carriers.[PMID 12451269]

• Among HIV+ men, the lifetime risk of developing Kaposi sarcoma is higher for rs1800795(G;G) homozygotes compared to (C;C) homozygotes.[PMID 11001912]

• Patients with Hodgkin's lymphoma who are rs1800795(G;G) were less likely to be successfully treated, with odds ratios for failure of 1.75 (CI: 1.04-2.92, p=0.03).[PMID 17496310]

• A study of 139 elderly males with acute coronary syndrome (ACS) indicated that rs1800795(G;G) genotypes were at 3.89 fold (CI: 1.71-8.86, p=0.001) higher risk of dying within one year of their ACS event than (C;G) or (C;C) genotypes.[PMID 16098388]

• Although the odds of having a stroke weren't different, among patients (in this case, under 60 years of age) who did have a stroke those with a rs1800795(G;G) genotype had more severe disability after 1 week (odds ratio 3.2, CI: 1.5-6.6, p=0.002).[PMID 14512079]

• Among Chinese patients with hypertension, the rs1800795(G) allele is more common, and (G;G) genotypes had significantly higher plasma PAI-1 activity than (C;C) genotypes.[PMID 15831362]

• In 168 Brazilian patients, rs1800795(G) allele frequency was higher in gastric cancer than in patients with chronic gastritis. [PMID 17560462]

• Although the odds of having Crohn's disease aren't affected, among 153 children with it, those with the rs1800795(G;G) genotype were more growth-retarded at diagnosis than (C;G) or (C;C) genotypes. (G;G) patients also had higher circulating levels of C-reactive protein (CRP).[PMID 16150725]

• rs1800795(G) carriers don't increase their high-density lipoprotein (HDL) levels after 24 weeks of aerobic exercise as much as rs1800795(C) carriers.[PMID 15904871]

• The rs1800795(G;G) genotype was more frequent in Australian infants with sudden infant death syndrome (58%) than in control subjects (38%, p=0.02).[PMID 17055359] This was not seen in a Norwegian population.[PMID 17509454]

• Women with endometriosis who are rs1800795(G) carriers appear to be more likely to develop chocolate cysts, and (G) allele carriers may be at slightly higher risk of developing endometriosis.[PMID 12517591]

• The rs1800795(G) allele is more frequent in women with hyperandrogenism than in controls.[PMID 11889177]

• Children with the rs1800795(G;G) genotype are more likely to have recurrent acute otitis, based on a study of 348 patients, with an odds ratio of 1.64 (p=0.02).[PMID 17908769]

• (G) allele is increased risk ((C) allele is decreased risk) for type-2 diabetes; this SNP is one of 4 relatively common SNPs reported to represent risk for type-2 diabetes in the DESIR prospective study of 3,877 Caucasian participants. Under an additive model, the odds ratio for rs1800795(C) carriers is 0.79 (CI: 0.65-0.96, p=0.01). For the 4 SNPs, each risk allele increased type-2 diabetes risk by 1.34x (p=2x10e-6), with an odds ratio of 2.48 (CI: 1.59-3.86) for carriers of 4 or more compared to those with one or none (risk alleles).[PMID 17977958]

The rs1800795(C) allele, generally associated with lower levels of IL6, has been associated with increased risk in these studies:

• rs1800795 (C;C) and (C;G) Caucasians who are excessively heavy (body mass index ~33 +/- 5kg/m2) are at increased risk (odds ratio 5.2, p=0.003) for developing obesity-related metabolic disorders such as hypertension, atherogenic dyslipidemia, and insulin resistance.[PMID 17998015]

• Among 571 patients with type-2 diabetes, the rs1800795(C) allele is correlated with higher body mass index, but it showed no correlation among non-diabetics.[PMID 15172007]

• A study of 238 Caucasians with type-2 diabetes concluded that rs1800795(C) carriers have an insulin resistance "IL-6-sensitive" phenotype and perhaps strategies to manage insulin resistance should be different between (C) carriers vs. (G;G) patients.[PMID 16140413]

• In patients with end-stage renal disease (ESRD) being treated by hemodialysis, rs1800795(C) allele carriers had higher diastolic blood pressure (p=0.008) and a higher left ventricular mass index (p=0.026) than (G;G) homozygotes. Among diabetic patients in dialysis, the prevalence of left ventricular hypertrophy in (C) allele carriers was 87.5% vs. 36.3% among (G;G) genotypes (p= 0.02).[PMID 12846758]

• Among recipient of a kidney transplant, rs1800795(C) allele carriers had worse three-year graft survival (71/104 = 68.3%; p=0.0059) with a 3.7-fold increased relative risk of graft loss compared to rs1800795(G;G) genotypes (48/54 = 88.9%). The authors suggest that determining the rs1800795 genotype may offer a new method for identifying patients at increased risk of allograft loss.[PMID 12371985]

• Among prostate cancer patients, the rs1800795(C) allele is associated with more aggressive cancer and higher prostate-specific antigen levels compared to rs1800795(G;G) homozygotes.[PMID 16006970]

• Although the rs1800795(C) allele was not associated with a higher frequency of heart attacks, it did have an association with inflammation and infarcts detectable only by MRI, suggesting that rs1800795(C) may chronically predispose an individual to develop atherosclerosis.[PMID 12482836]

• The combination of carrying at least one rs1800795(C) and one rs1205(T), a SNP in the C-reactive protein gene, led to higher risk of a stroke after cardiac surgery (odds ratio 3.3, CI: 1.4-8.1, p=0.0023) compared to individuals who were rs1800795(G;G) and rs1205(C;C).[PMID 16051899]

• The rs1800795(C) allele was associated with higher postoperative IL6 levels and a less favorable clinical outcome following coronary revascularization surgery.[PMID 16183563]

• The rs1800795(C;C) genotype was significantly higher in the group of 122 adult periodontitis patients than in controls (odds ratio 1.896, CI: 1.1-3.2, p=0.0283).[PMID 17209781]

• The degree of periodontitis was more severe in rs1800795(C) carriers than (G) carriers.[PMID 17286759]

• The rs1800795(C) allele was over-represented in patients with Alzheimer's disease compared to controls and the (C;C) genotype was associated with higher risk in women.[PMID 12928051]

• The rs1800795(C) allele was higher in non-survivors compared to (nonagenarian) survivors in a case/control study of ~100 pairs of matched Finnish individuals; to put it another way, the rs1800795(G) allele may be associated with increased longevity.[PMID 15664628]

[PMID 18257935] rs1800797, rs1800796 and rs1800795 have been shown to affect both the transcription and secretion of IL-6, to symptomatic distal interphalangeal osteoarthritis based on 535 women. the G alleles of two promoter single-nucleotide polymorphisms (SNP) G-597A and G-174C were more common among the subjects with symptomatic DIP OA than among those with no disease (p-values corrected for multiple testing 0.020 and 0.024). Also, the carriage of at least one G allele in these positions increased the risk of disease (p=0.006 and, p=0.008, respectively). Carrying a haplotype with the G allele in all three promoter SNPs increased the risk of symptomatic DIP OA more than four-fold (OR 4.45, p=0.001). Carriage of the G-G diplotype indicated an increased risk of both symmetrical DIP OA (OR 1.52 95% CI 1.01 to 2.28) and symptomatic DIP OA (OR 3.67 95% CI 1.50 to 9.00)

[PMID 18056967] Suggests that "healthy elderly individuals may have a proinflammatory profile playing as a downregulating factor for inducible Hsp70, particularly if -174 G/C-negative" and that therefore, a nutraceutical intervention (fermented papaya preparation 9 g/day) might be of benefit.

[PMID 18449426] rs1800795 coronary artery disease 190 affected Asian Indian sibling pairs

[PMID 19280716] The IL6-174G/C polymorphism is associated with celiac disease susceptibility in girls.

[PMID 19435922] Host genetic variants in the interleukin-6 promoter predict poor outcome in patients with estrogen receptor-positive, node-positive breast cancer

[PMID 19671870] Prognostic Significance of Interleukin-6 Single Nucleotide Polymorphism Genotypes in Neuroblastoma: rs1800795 (Promoter) and rs8192284 (Receptor)

[PMID 19452524] Tumor markers and rectal cancer: support for an inflammation-related pathway

[PMID 19387461] Interleukin-6 haplotypes and the response to therapy of chronic hepatitis C virus infection

[PMID 19833146] Sex-specific effects of CNTF, IL6 and UCP2 polymorphisms on weight gain

[PMID 19853505] The -174 G/C polymorphism of the IL6 gene is associated with elite power performance

[PMID 20043205] Lack of an association between a functional polymorphism in the interleukin-6 gene promoter and breast cancer risk: a meta-analysis involving 25,703 subjects

[PMID 20132806] Study of TNFalpha -308 G/A and IL6 -174 G/C polymorphisms in type 2 diabetes and obesity risk in the Tunisian population

[PMID 20149313] Interleukin-6 gene -174 promoter polymorphism is associated with endothelial dysfunction but not with disease susceptibility in patients with rheumatoid arthritis

[PMID 20176930] Computational identification of gene-social environment interaction at the human IL6 locus

[PMID 20175976] A meta-analysis of interleukin-6 promoter polymorphisms on risk of hip and knee osteoarthritis

[PMID 20044998] Genetic risk factors for post-infectious irritable bowel syndrome following a waterborne outbreak of gastroenteritis

[PMID 20592333] The increased plasma C-reactive protein and interleukin-6 levels in patients undergoing coronary artery bypass grafting surgery are associated with the interleukin-6-174G > C gene polymorphism

[PMID 20333461] Serum CRP and IL-6, genetic variants and risk of colorectal adenoma in a multiethnic population

[PMID 21291465] The association of genetic polymorphisms with cerebral palsy: a meta-analysis

OMIM	147620
Desc
Variant
Related	also

[PMID 21736829] Gene-PUFA interactions and obesity risk

[PMID 21889771] Lack of association between IL6 single nucleotide polymorphisms and cardiovascular disease in Spanish patients with rheumatoid arthritis

[PMID 22015309] MTHFR (677 and 1298) and IL-6-174 G/C genes in pathogenesis of Alzheimer's and vascular dementia and their epistatic interaction

[PMID 22107760] Genetic susceptibility of intervertebral disc degeneration among young Finnish adults

[PMID 22115178] Insulin-like growth factor 1 receptor polymorphism rs2229765 and circulating interleukin-6 level affect male longevity in a population-based prospective study (Treviso Longeva- TRELONG)

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[PMID 22459738] Genetic and Immunological Evidence Implicates Interleukin 6 as a Susceptibility Gene for Leprosy Type 2 Reaction

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[PMID 22475653] Genetic predictors of fatigue in prostate cancer patients treated with androgen deprivation therapy: Preliminary findings

[PMID 22571276] Interleukin-6 promoter polymorphism and plasma levels in patients with schizophrenia

[PMID 22642105] [Polymorphic variants of genes encoding interleukin-6 and fibrinogen, the risk of ischemic stroke and fibrinogen levels]

[PMID 22695063] Interleukin-6 gene (IL-6): a possible role in brain morphology in the healthy adult brain

[PMID 22734797] Association Between -174 Interleukin-6 Gene Polymorphism and Biological Response to Rituximab in Several Systemic Autoimmune Diseases

[PMID 15113403] Current limitations of SNP data from the public domain for studies of complex disorders: a test for ten candidate genes for obesity and osteoporosis.

[PMID 15726497] Gene-environment interaction effects on the development of immune responses in the 1st year of life.

[PMID 15820616] IL-6 gene variation is not associated with increased serum levels of IL-6, muscle, weakness, or frailty in older women.

[PMID 16046815] Data-mining analysis suggests an epigenetic pathogenesis for type 2 diabetes.

[PMID 16449530] Cytokine polymorphisms in the Th1/Th2 pathway and susceptibility to non-Hodgkin lymphoma.

[PMID 16544245] Host immunogenetics and control of human herpesvirus-8 infection.

[PMID 16617143] Algorithm for automatic genotype calling of single nucleotide polymorphisms using the full course of TaqMan real-time data.

[PMID 16644865] Genetic variation in IL6 gene and type 2 diabetes: tagging-SNP haplotype analysis in large-scale case-control study and meta-analysis.

[PMID 16759385] Cytokine gene polymorphisms and atopic disease in two European cohorts. (ECRHS-Basel and SAPALDIA).

[PMID 16820586] Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery.

[PMID 16842617] Interleukin gene polymorphisms and breast cancer: a case control study and systematic literature review.

[PMID 16846490] Lemierre's syndrome and genetic polymorphisms: a case report.

[PMID 17003362] IL6 gene promoter polymorphisms and type 2 diabetes: joint analysis of individual participants' data from 21 studies.

[PMID 17327408] Prognostic significance of host immune gene polymorphisms in follicular lymphoma survival.

[PMID 17416766] IL6, aspirin, nonsteroidal anti-inflammatory drugs, and breast cancer risk in women living in the southwestern United States.

[PMID 17594514] Active and passive smoking, IL6, ESR1, and breast cancer risk.

[PMID 17623760] Interleukin-6 genetic variability and adiposity: associations in two prospective cohorts and systematic review in 26,944 individuals.

[PMID 17665434] Association of interleukin-6 and interleukin-10 genotypes with radiographic damage in rheumatoid arthritis is dependent on autoantibody status.

[PMID 17694420] IL6 genotypes and colon and rectal cancer.

[PMID 17705862] Optimization of candidate-gene SNP-genotyping by flexible oligonucleotide microarrays; analyzing variations in immune regulator genes of hay-fever samples.

[PMID 17847004] Common variants in the BMP2, BMP4, and HJV genes of the hepcidin regulation pathway modulate HFE hemochromatosis penetrance.

[PMID 17903293] Genome-wide association with select biomarker traits in the Framingham Heart Study.

[PMID 17916900] Single-nucleotide polymorphisms in selected cytokine genes and risk of adult glioma.

[PMID 17996468] Polymorphisms of the interleukin-6 gene promoter and abdominal aortic aneurysm.

[PMID 18041006] Association of TGF-beta1 codon 25 (G915C) polymorphism with hepatitis C virus infection.

[PMID 18045485] The candidate genes TAF5L, TCF7, PDCD1, IL6 and ICAM1 cannot be excluded from having effects in type 1 diabetes.

[PMID 18216863] Genetic determinants of basal C-reactive protein expression in Filipino systemic lupus erythematosus families.

[PMID 18239642] Modifying effects of IL-6 polymorphisms on body size-associated breast cancer risk.

[PMID 18276608] Interleukin-6 (IL-6) and receptor (IL6-R) gene haplotypes associate with amniotic fluid protein concentrations in preterm birth.

[PMID 18307517] Common studied polymorphisms do not affect plasma cytokine levels upon endotoxin exposure in humans.

[PMID 18321738] Is the interleukin-6 haplotype a prognostic factor for sciatica?

[PMID 18420533] The effect of IL6-174C/G polymorphism on postprandial triglyceride metabolism in the GOLDN studyboxs.

[PMID 18436879] Biomarkers of Inflammation and MRI-Defined Small Vessel Disease of the Brain: The Cardiovascular Health Study.

[PMID 18458677] Functional polymorphisms in the interleukin-6 and serotonin transporter genes, and depression and fatigue induced by interferon-alpha and ribavirin treatment.

[PMID 18496509] An IL-6 haplotype on human chromosome 7p21 confers risk for impaired renal function in type 2 diabetic patients.

[PMID 18500540] Fine-mapping the genetic basis of CRP regulation in African Americans: a Bayesian approach.

[PMID 18505952] Genetic susceptibility to cancer: the role of polymorphisms in candidate genes.

[PMID 18603647] Functional genetic polymorphisms and female reproductive disorders: Part I: Polycystic ovary syndrome and ovarian response.

[PMID 18633131] Host immune gene polymorphisms in combination with clinical and demographic factors predict late survival in diffuse large B-cell lymphoma patients in the pre-rituximab era.

[PMID 18676870] Variants in inflammation genes and the risk of biliary tract cancers and stones: a population-based study in China.

[PMID 18687755] Genetic variants in T helper cell type 1, 2 and 3 pathways and gastric cancer risk in a Polish population.

[PMID 18689695] Predicting diabetes: clinical, biological, and genetic approaches: data from the Epidemiological Study on the Insulin Resistance Syndrome (DESIR).

[PMID 18752089] Joint analysis of individual participants' data from 17 studies on the association of the IL6 variant -174G>C with circulating glucose levels, interleukin-6 levels, and body mass index.

[PMID 18781131] Interleukin and interleukin receptor gene polymorphisms and susceptibility to melanoma.

[PMID 18787421] Genetic contributions to disparities in preterm birth.

[PMID 18805939] Functional genetic polymorphisms and female reproductive disorders: part II--endometriosis.

[PMID 18992148] Low-penetrance alleles predisposing to sporadic colorectal cancers: a French case-controlled genetic association study.

[PMID 18992263] Colon tumor mutations and epigenetic changes associated with genetic polymorphism: insight into disease pathways.

[PMID 19034965] Genetic determination of irritable bowel syndrome.

[PMID 19035456] Adipokine genes and prostate cancer risk.

[PMID 19056105] DNA variants, plasma levels and variability of interleukin-6 in myocardial infarction survivors: results from the AIRGENE study.

[PMID 19066394] Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphoma.

[PMID 19106168] Transforming growth factor-beta1 869T/C, but not interleukin-6 -174G/C, polymorphism associates with hypertension in rheumatoid arthritis.

[PMID 19124510] Insulin-like growth factor-1- and interleukin-6-related gene variation and risk of multiple myeloma.

[PMID 19131662] A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.

[PMID 19131814] Variation in the TLR4 gene influences the risk of organ failure and shock posttrauma: a cohort study.

[PMID 19140096] The -174G>C IL-6 gene promoter polymorphism and diabetic microvascular complications.

[PMID 19147066] Genomic and proteomic analysis of allogeneic hematopoietic cell transplant outcome. Seeking greater understanding the pathogenesis of GVHD and mortality.

[PMID 19249341] Inflammation and stress-related candidate genes, plasma interleukin-6 levels, and longevity in older adults.

[PMID 19263529] Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach.

[PMID 19267250] C-reactive protein, interleukin-6, and prostate cancer risk in men aged 65 years and older.

[PMID 19272152] IL6 and CRP haplotypes are associated with COPD risk and systemic inflammation: a case-control study.

[PMID 19330901] Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study.

[PMID 19347053] Analysis of inflammation- and atherosclerosis-related gene polymorphisms in branch retinal vein occlusion.

[PMID 19356949] Cytokine SNPs: Comparison of allele frequencies by race and implications for future studies.

[PMID 19359268] Associations of IL6 polymorphisms with lung function decline and COPD.

[PMID 19377912] Interleukin-6 plasma level increases with age in an Italian elderly population ("The Treviso Longeva"-Trelong-study) with a sex-specific contribution of rs1800795 polymorphism.

[PMID 19401444] Body iron stores and glucose intolerance in premenopausal women: role of hyperandrogenism, insulin resistance, and genomic variants related to inflammation, oxidative stress, and iron metabolism.

[PMID 19478423] Cytokine response to vitamin E supplementation is dependent on pre-supplementation cytokine levels.

[PMID 19503017] Genetic ancestry modifies pharmacogenetic gene-gene interaction for asthma.

[PMID 19505919] Toll-like receptor signaling pathway variants and prostate cancer mortality.

[PMID 19542902] The -174GG interleukin-6 genotype is protective from retinopathy and nephropathy in juvenile onset type 1 diabetes mellitus.

[PMID 19559392] A candidate gene association study of 77 polymorphisms in migraine.

[PMID 19592000] Interleukin-6 promoter polymorphism and cardiovascular risk factors: the Health 2000 Survey.

[PMID 19698145] Replication by the Epistasis Project of the interaction between the genes for IL-6 and IL-10 in the risk of Alzheimer's disease.

[PMID 19729864] Association of genetic variation in serum amyloid-A with cardiovascular disease and interactions with IL6, IL1RN, IL1beta and TNF genes in the Cardiovascular Health Study.

{{PMID Auto |PMID=19734419 |Title=A polymorphism in NFKB1 is associated with improved effect of interferon-{alpha} maintenance treatment of patients with multiple myeloma after high-dose treatment with stem cell support. |OA=1 }}

[PMID 19750100] Modification of the interleukin-6 response to air pollution by interleukin-6 and fibrinogen polymorphisms.

[PMID 19876004] Obesity-related polymorphisms and their associations with the ability to regulate fat oxidation in obese Europeans: the NUGENOB study.

[PMID 19912668] Design and evaluation of a treatment programme for Spanish adolescents with overweight and obesity. The EVASYON Study.

[PMID 19942621] An integrated expression phenotype mapping approach defines common variants in LEP, ALOX15 and CAPNS1 associated with induction of IL-6.

[PMID 20031584] Genetics of atherothrombotic and lacunar stroke.

[PMID 20144192] Chromosome 7p linkage and association study for diabetes related traits and type 2 diabetes in an African-American population enriched for nephropathy.

[PMID 20361391] The rs1800629 polymorphism in the TNF gene interacts with physical activity on the changes in C-reactive protein levels in the Finnish Diabetes Prevention Study.

[PMID 20436380] Lack of association between the promoter polymorphisms of MMP-3 and IL-6 genes and adolescent idiopathic scoliosis: a case-control study in a Chinese Han population.

[PMID 20463618] Role of polymorphic variants as genetic modulators of infection in neonatal sepsis.

[PMID 20565774] Population based allele frequencies of disease associated polymorphisms in the Personalized Medicine Research Project.

[PMID 20585578] The interaction between coagulation factor 2 receptor and interleukin 6 haplotypes increases the risk of myocardial infarction in men.

[PMID 20622166] Combined effect of inflammatory gene polymorphisms and the risk of ischemic stroke in a prospective cohort of subjects with type 2 diabetes: a Go-DARTS study.

[PMID 20811626] Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer.

[PMID 21278902] Genetic risk profiling for prediction of type 2 diabetes.

[PMID 21385363] Polymorphisms in genes controlling inflammation and tissue repair in rheumatoid arthritis: a case control study.

[PMID 21496483] Fatigued breast cancer survivors and gene polymorphisms in the inflammatory pathway.

[PMID 21536090] Lack of an association between interleukin-6 gene promoter polymorphisms (-174G/C, -572G/C) and ischemic heart disease and/or ischemic stroke: a meta-analysis.

[PMID 21621860] Association of IL1A, IL1B, ILRN, IL6, IL10 and TNF-alpha polymorphisms with risk and clinical course of multiple sclerosis in a Polish population.

[PMID 22024650] Association between IL-6 -174G/C polymorphism and acute rejection of renal allograft: evidence from a meta-analysis.

[PMID 22070425] Profile of inflammatory mediators in gestational diabetes mellitus: phenotype and genotype.

[PMID 22075267] Replication and meta-analysis of the gene-environment interaction between body mass index and the interleukin-6 promoter polymorphism with higher insulin resistance.

[PMID 22155094] Gender differences in the IL6 -174G>C and ESR2 1730G>A polymorphisms and the risk of Parkinson's disease.

[PMID 22372709] Cytokine gene polymorphisms in the susceptibility to acute coronary syndrome.

[PMID 22565057] The -174G/C variant of IL6 as risk factor for mortality and technique failure in a large cohort of peritoneal dialysis patients.

[PMID 23050050] Gender difference in genetic association between IL1A variant and early lumbar disc degeneration: a three-year follow-up

[PMID 23470916] Association of the 174 G/C polymorphism of the IL6 gene in Polish power-orientated athletes

[PMID 23482714] Preliminary Evidence of an Association Between an Interleukin 6 Promoter Polymorphism and Self-Reported Attentional Function in Oncology Patients and Their Family Caregivers

[PMID 23487197] Association of Interleukin 2 (IL-2), Interleukin 6 (IL-6), and TNF-alpha (TNFα) Gene Polymorphisms With Paranoid Schizophrenia in a Polish Population

[PMID 23571152] Serotonin and interleukin-6: The role of genetic polymorphisms in IFN-induced neuropsychiatric symptoms

[PMID 23617681] Effect of interleukin-6 polymorphism on risk of preterm birth within population strata: a meta-analysis

[PMID 23681449] Genes for Elite Power and Sprint Performance: ACTN3 Leads the Way

[PMID 23013217] Analysis of polymorphisms in interleukin-10, interleukin-6, and interleukin-1 receptor antagonist in Mexican-Mestizo women with pre-eclampsia

[PMID 23881440] Association between interleukin 6 and interleukin 16 gene polymorphisms and coronary heart disease risk in a Chinese population

[PMID 24072654] Influence of interleukin gene polymorphisms on development of acute pancreatitis: a systematic review and meta-analysis

[PMID 24140476] Genetic variations in IL6 and IL12B decreasing the risk for psoriasis

[PMID 24204677] Impact of interleukin-6 -174 g>c gene promoter polymorphism on neuroblastoma

[PMID 24253594] Confirmation of -174G/C interleukin-6 gene promoter polymorphism as a genetic marker predicting antitumor necrosis factor treatment outcome

[PMID 24314052] Sequencing of the IL6 gene in a case--control study of cerebral palsy in children

[PMID 24495605] Increased serum interleukin-6 levels in early stages of psychosis: Associations with at-risk mental states and the severity of psychotic symptoms

[PMID 22038464] Moderate effects of apple juice consumption on obesity-related markers in obese men: impact of diet-gene interaction on body fat content.

[PMID 22711691] Associations between interleukin-6 gene -174 C/G and -572 C/G polymorphisms and the risk of gastric cancer: a meta-analysis.

[PMID 22714907] IL6 gene polymorphisms and susceptibility to colorectal cancer: a meta-analysis and review.

[PMID 22749237] Tumor necrosis factor -308 polymorphism (rs1800629) is associated with mortality and ventilator duration in 1057 Caucasian patients.

[PMID 22761283] Multigene interactions and the prediction of depression in the Wisconsin Longitudinal Study.

[PMID 22818022] Polymorphic variations in IL-1beta, IL-6 and IL-10 genes, their circulating serum levels and breast cancer risk in Indian women.

[PMID 23027890] Influence of the IL6 gene in susceptibility to systemic sclerosis.

[PMID 23029430] Prognostic role of host cyclooxygenase and cytokine genotypes in a Caucasian cohort of patients with gastric adenocarcinoma.

[PMID 23107763] Host genetic risk factors for community-acquired pneumonia.

[PMID 23133602] Pharmacogenetics of efficacy and safety of HCV treatment in HCV-HIV coinfected patients: significant associations with IL28B and SOCS3 gene variants.

[PMID 23357300] Role of inflammatory gene polymorphisms in left ventricular dysfunction (LVD) susceptibility in coronary artery disease (CAD) patients.

[PMID 23459936] Exploring the genetic basis of chronic periodontitis: a genome-wide association study.

[PMID 23530106] Cytokine genetic variations and fatigue among patients with breast cancer.

[PMID 23533647] Polymorphisms in the calcium-sensing receptor gene are associated with clinical outcome of neuroblastoma.

[PMID 24008079] Cytokine gene polymorphisms and progression-free survival in classical Hodgkin lymphoma by EBV status: results from two independent cohorts

[PMID 24059848] Interleukin-6 polymorphisms and hematologic malignancy: a re-appraisal of evidence from genetic association studies

[PMID 24974143] Association of interleukin 6 single nucleotide polymorphisms with allergic rhinitis

[PMID 25030201] Association between Interleukin-6 Gene Polymorphisms and Rheumatoid Arthritis in Chinese Han Population: A Case-Control Study and A Meta-analysis

[PMID 25127106] Polymorphisms in the TNFA and IL6 Genes Represent Risk Factors for Autoimmune Thyroid Disease

[PMID 25564959] CD38 and Interleukin 6 Gene Polymorphism in Egyptians with Diffuse Large B-Cell Lymphoma (DLBCL)

[PMID 25807366] Urinary Proteins, Vitamin D and Genetic Polymorphisms as Risk Factors for Febrile Urinary Tract Infection and Relation with Bacteremia: A Case Control Study

[PMID 25839939] Genetic association of IL-6, TNF-α and SDF-1 polymorphisms with serum cytokine levels in diabetic foot ulcer

[PMID 25993353] Association of IL-6 and CRP gene polymorphisms with obesity and metabolic disorders in children and adolescents

[PMID 25305747] IL6 genotype, tumour ER-status, and treatment predicted disease-free survival in a prospective breast cancer cohort

[PMID 26025100] Association of tumor necrosis factor α -308G/A and interleukin-6 -174G/C gene polymorphism with pneumonia-induced sepsis

[PMID 25299085] IL-6 gene promoter polymorphisms and risk of coronary artery disease in a Chinese population

[PMID 25422198] Polymorphic variation of inflammation-related genes and risk of non-Hodgkin lymphoma for Uygur and Han Chinese in Xinjiang

[PMID 26199858] Role of the IL-6 Gene in the Etiopathogenesis of Idiopathic Scoliosis

[PMID 26198920] Family-based association study of interleukin 6 (IL6) and its receptor (IL6R) functional polymorphisms in schizophrenia in the Polish population

[PMID 25566937] A genetic study on C5-TRAF1 and progression of joint damage in rheumatoid arthritis

[PMID 26511189] INTERLEUKIN-6 GENE POLYMORPHISM MODULATES THE RISK OF PERIODONTAL DISEASES

[PMID 26535651] Role of interleukin-6 gene polymorphisms in the development of prostate cancer

[PMID 26578807] Genetic polymorphism directs IL-6 expression in fibroblasts but not selected other cell types

[PMID 27159547] Adipokine Gene Single-Nucleotide Polymorphisms in Portuguese Obese Adolescents: Associations with Plasma Concentrations of Adiponectin, Resistin, IL-6, IL-1β, and TNF-α.

[PMID 27535759] Polymorphisms of the interleukin 6 gene and additional gene-gene interaction contribute to cervical cancer susceptibility in Eastern Chinese women.

[PMID 27559091] Influence of cytokine gene polymorphisms on proinflammatory/anti-inflammatory cytokine imbalance in premature coronary artery disease.

[PMID 27662210] IL6-174 G>C Polymorphism (rs1800795) Association with Late Effects of Low Dose Radiation Exposure in the Portuguese Tinea Capitis Cohort.

[PMID 27777338] Association Between the IL-6 rs1800795 Polymorphism and the Risk of Cervical Cancer: A Meta-Analysis of 1210 Cases and 1525 Controls.

[PMID 27840402] Promoter Polymorphism (-174, G/C) of Interleukin-6 and Arterial Thromboembolic Events: A Meta-Analysis.

[PMID 28268030] Influence of IL1B, IL6 and IL10 gene variants and plasma fatty acid interaction on metabolic syndrome risk in a cross-sectional population-based study.

[PMID 28403117] Association of the ACE, GSTM1, IL-6, NOS3, and CYP1A1 polymorphisms with susceptibility of mycoplasma pneumoniae pneumonia in Chinese children.

[PMID 28555011] The IL-6 Gene Promoter SNP and Plasma IL-6 in Response to Diet Intervention.

[PMID 28593468] Association of the IL6 rs1800796, but not of the IL6 rs1800795, IL6R rs4845617 and rs2228145 polymorphisms with hip fracture in elderly Mexican women.

[PMID 28732081] IL-6 variant is associated with metastasis in breast cancer patients.

[PMID 28739396] Genetic association of pro-inflammatory cytokine gene polymorphisms with coronary artery disease (CAD) in a North Indian population.

[PMID 29042807] Association between interleukin-6/6R gene polymorphisms and coronary artery disease in Russian population: influence of interleukin-6/6R gene polymorphisms on inflammatory markers.

[PMID 29666343] Interleukin gene polymorphisms and susceptibility to HIV-1 infection: a meta-analysis.

[PMID 29692379] Serum Interleukin-6 Level and the rs1800795 Polymorphism in its Gene Associated with Neuroblastoma Risk in Chinese Children.

[PMID 30009916] Single nucleotide polymorphisms in cytokine/chemokine genes are associated with severe infection, ulcer grade and amputation in diabetic foot ulcer.

[PMID 30069682] Association of interleukin 6, interleukin 7 receptor alpha, and interleukin 12B gene polymorphisms with multiple sclerosis.

[PMID 31082334] [Correlation between interleukin-6 single nucleotide polymorphism and the occurrence and prognosis of hepatitis B virus-associated acute-on-chronic liver failure].

[PMID 31132388] Investigating the contribution of NPSR1, IL-6 and BDNF polymorphisms to depressive and anxiety symptoms in hemodialysis patients.

[PMID 31301734] Impact of interleukin-6 gene polymorphisms and its interaction with obesity on osteoporosis risk in Chinese postmenopausal women.

[PMID 31615448] Candidate single nucleotide polymorphisms of irritable bowel syndrome: a systemic review and meta-analysis.

[PMID 31618972] Polymorphisms of Proinflammatory Cytokines in Relation to APOE Epsilon 4 and Risk of Alzheimer's Disease in the Lithuanian Population.

[PMID 31929778] Association between Hepatitis C Virus Viremia and the rs12979860, rs2228145 and rs1800795 SNP (CT/AC/GG) Genotype in Saudi Kidney Transplant Recipients.

[PMID 32046104] The Impact of IL-6 and IL-10 Gene Polymorphisms in Diffuse Large B-Cell Lymphoma Risk and Overall Survival in an Arab Population: A Case-Control Study.

[PMID 32391092] Association of angiogenesis and inflammation-related gene functional polymorphisms with early-stage breast cancer prognosis.

[PMID 32330537] Associations of IL6 rs1800795, BLK rs13277113, TIMP3 rs9621532, IL1RL1 rs1041973 and IL1RAP rs4624606 single gene polymorphisms with laryngeal squamous cell carcinoma.

[PMID 32432788] Effects of gene polymorphism and serum levels of IL-2 and IL-6 on endometriosis.

[PMID 32543936] Impact of IL-17F 7488T/C Functional Polymorphism on Progressive Rheumatoid Arthritis: Novel Insight from the Molecular Dynamic Simulations.

[PMID 32602796] Association of Polymorphisms in Cytokine genes with susceptibility to Precancerous Lesions and Cervical Cancer: A systematic review with meta-analysis.

[PMID 32685106] Interleukin-6-174G/C polymorphism is associated with a decreased risk of type 2 diabetes in patients with chronic hepatitis C virus.

[PMID 33016995] The association of Interieukin-6 polymorphism (rs1800795) with microvascular complications in type 2 diabetes mellitus.

[PMID 33359288] Polymorphisms in the IL-6 and TNF-α gene are associated with an increased risk of abdominal aortic aneurysm.