rs1805097
Orientation | minus |
Stabilized | minus |
Geno | Mag | Summary |
---|---|---|
(A;A) | twice as likely to reach extreme old age? | |
(A;G) | normal | |
(G;G) | normal |
Reference | GRCh38 38.1/141 |
Chromosome | 13 |
Position | 109782884 |
Gene | IRS2 |
is a | snp |
is | mentioned by |
dbSNP | rs1805097 |
dbSNP (classic) | rs1805097 |
ClinGen | rs1805097 |
ebi | rs1805097 |
HLI | rs1805097 |
Exac | rs1805097 |
Gnomad | rs1805097 |
Varsome | rs1805097 |
LitVar | rs1805097 |
Map | rs1805097 |
PheGenI | rs1805097 |
Biobank | rs1805097 |
1000 genomes | rs1805097 |
hgdp | rs1805097 |
ensembl | rs1805097 |
geneview | rs1805097 |
scholar | rs1805097 |
rs1805097 | |
pharmgkb | rs1805097 |
gwascentral | rs1805097 |
openSNP | rs1805097 |
23andMe | rs1805097 |
SNPshot | rs1805097 |
SNPdbe | rs1805097 |
MSV3d | rs1805097 |
GWAS Ctlg | rs1805097 |
GMAF | 0.2971 |
Max Magnitude | 0 |
rs1805097, also known as Gly1057Asp, is a SNP in the insulin receptor substrate-2 IRS2 gene. The rs1805097(G) allele is associated with the Gly, and the (A) allele with Asp.
A longevity study categorizing 677 participants as either long-lived (i.e. over 85 years old) or not (less than 85) somehow concluded that rs1805097(A;A) individuals were about twice as likely to reach extreme old age (odds ratio 2.03, CI:1.39-2.99, p = .0003).[PMID 19887537]
[PMID 19818665] Apolipoprotein E genotype is associated with serum C-reactive protein but not abdominal aortic aneurysm
ClinVar | |
---|---|
Risk | Rs1805097(A;A) |
Alt | Rs1805097(A;A) |
Reference | Rs1805097(G;G) |
Significance | Other |
Disease | DIABETES |
Variation | info |
Gene | IRS2 |
CLNDBN | DIABETES, TYPE II, SUSCEPTIBILITY TO |
Reversed | 1 |
HGVS | NC_000013.10:g.110435231C>T |
CLNSRC | OMIM Allelic Variant UniProtKB (protein) |
CLNACC | RCV000009368.3, |
[PMID 18398040] Transcription factor 7-like 2 polymorphism and colon cancer.
[PMID 18603647] Functional genetic polymorphisms and female reproductive disorders: Part I: Polycystic ovary syndrome and ovarian response.
[PMID 18611262] Genetic variation in candidate obesity genes ADRB2, ADRB3, GHRL, HSD11B1, IRS1, IRS2, and SHC1 and risk for breast cancer in the Cancer Prevention Study II.
[PMID 18992263] Colon tumor mutations and epigenetic changes associated with genetic polymorphism: insight into disease pathways.
[PMID 19124510] Insulin-like growth factor-1- and interleukin-6-related gene variation and risk of multiple myeloma.