||higher risk for migraine in 1 study which has not replicated
||unreplicated, higher risk for migraine
|?|| (A;A) (A;G) (G;G) ||28|
rs1835740 is a SNP from the 8q22.1 chromosomal region, best known for harboring various genes involved in glutamate metabolism and transport.
A large study comprising over 5,000 migraine patients and over 10,000 matched controls, primarily from Europe, found that the rs1835740(A) allele conferred a (slightly) higher risk for the disorder. The reported odds ratio was 1.18, (CI: 1.127–1.244, p = 1.69 × 10e-11).[PMID 20802479]. However this study has failed to replicate in 2 followups.
[PMID 22072275] Genetics of migraine in the age of genome-wide association studies
[PMID 22103325] A genotype-phenotype analysis of the 8q22.1 variant in migraine with aura
[PMID 21964821] Genotype-phenotype correlation in migraine without aura focusing on the rs1835740 variant on 8q22.1.
[PMID 22908361] A replication study of a GWAS finding in migraine does not identify association in a Spanish case-control sample.
[PMID 24674449] A replication study of GWAS findings in migraine identifies association in a Swedish case-control sample
[PMID 30382894] Implications for the migraine SNP rs1835740 in a Swedish cluster headache population.