rs1997794
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (T;T) | 0 | common in clinvar |
| Make rs1997794(C;C) |
| Make rs1997794(C;T) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 20 |
| Position | 1994212 |
| Gene | LOC727993, PDYN |
| is a | snp |
| is | mentioned by |
| dbSNP | rs1997794 |
| dbSNP (classic) | rs1997794 |
| ClinGen | rs1997794 |
| ebi | rs1997794 |
| HLI | rs1997794 |
| Exac | rs1997794 |
| Gnomad | rs1997794 |
| Varsome | rs1997794 |
| LitVar | rs1997794 |
| Map | rs1997794 |
| PheGenI | rs1997794 |
| Biobank | rs1997794 |
| 1000 genomes | rs1997794 |
| hgdp | rs1997794 |
| ensembl | rs1997794 |
| geneview | rs1997794 |
| scholar | rs1997794 |
| rs1997794 | |
| pharmgkb | rs1997794 |
| gwascentral | rs1997794 |
| openSNP | rs1997794 |
| 23andMe | rs1997794 |
| SNPshot | rs1997794 |
| SNPdbe | rs1997794 |
| MSV3d | rs1997794 |
| GWAS Ctlg | rs1997794 |
| GMAF | 0.4109 |
| Max Magnitude | 0 |
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
|
| ||
[PMID 19468819] Gene polymorphisms in prodynorphin (PDYN) are associated with episodic memory in the elderly
[PMID 19298317] An association of prodynorphin polymorphisms and opioid dependence in females in a Chinese population
[PMID 21338584] Prodynorphin promoter SNP associated with alcohol dependence forms noncanonical AP-1 binding site that may influence gene expression in human brain
[PMID 22764240
] Dynorphins regulate fear memory: from mice to men
[PMID 18923396] A functional haplotype implicated in vulnerability to develop cocaine dependence is associated with reduced PDYN expression in human brain.
[PMID 22443215] Genetic association analyses of PDYN polymorphisms with heroin and cocaine addiction.
[PMID 23101464] Association of the PDYN gene with alcohol dependence and the propensity to drink in negative emotional states
[PMID 26029055] Downregulation of the endogenous opioid peptides in the dorsal striatum of human alcoholics
[PMID 28656735] An analysis of genetic association in opioid dependence susceptibility.
| ClinVar | |
|---|---|
| Risk | rs1997794(C;C) |
| Alt | rs1997794(C;C) |
| Reference | Rs1997794(T;T) |
| Significance | Non-pathogenic |
| Disease | Spinocerebellar Ataxia |
| Variation | info |
| Gene | PDYN LOC727993 |
| CLNDBN | Spinocerebellar Ataxia, Dominant |
| Reversed | 0 |
| HGVS | NC_000020.10:g.1974858T>C |
| CLNSRC | |
| CLNACC | RCV000273681.1, |
[PMID 29925858] Downregulation of the neuronal opioid gene expression concomitantly with neuronal decline in dorsolateral prefrontal cortex of human alcoholics.
