rs2076756

plus

Geno	Mag	Summary
(A;A)	0	normal
(A;G)		?
(G;G)		1.7x increased risk for Crohn's disease

Reference

GRCh38 38.1/141

Chromosome

16

Position

50722970

Gene

NOD2

is a	snp
is	mentioned by
dbSNP	rs2076756
dbSNP (classic)	rs2076756
ClinGen	rs2076756
ebi	rs2076756
HLI	rs2076756
Exac	rs2076756
Gnomad	rs2076756
Varsome	rs2076756
LitVar	rs2076756
Map	rs2076756
PheGenI	rs2076756
Biobank	rs2076756
1000 genomes	rs2076756
hgdp	rs2076756
ensembl	rs2076756
geneview	rs2076756
scholar	rs2076756
google	rs2076756
pharmgkb	rs2076756
gwascentral	rs2076756
openSNP	rs2076756
23andMe	rs2076756
SNPshot	rs2076756
SNPdbe	rs2076756
MSV3d	rs2076756
GWAS Ctlg	rs2076756

GMAF

0.1148

Max Magnitude

0

?

(A;A) (A;G) (G;G)

28

rs2076756 is a SNP of the NOD2 gene found in a genome-wide association study to be associated with Crohn's disease.

In several European populations, the minor NOD2 allele, rs2076756(G), is associated with increased risk for Crohn's disease. The odds ratio (pooled over several populations) is 1.71 (CI: 1.42-2.05, p=6x10^-8).[PMID 17684544 ]

GWAS snp
PMID	[PMID 17435756 ]
Trait	Crohn's disease
Title	Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis
Risk Allele
P-val	7.0000000000000005E-14
Odds Ratio	NR NR

GWAS snp
PMID	[PMID 17068223 ]
Trait	Inflammatory bowel disease
Title	A genome-wide association study identifies IL23R as an inflammatory bowel disease gene
Risk Allele
P-val	5.0000000000000003E-10
Odds Ratio	NR NR

GWAS snp
PMID	[PMID 21102463 ]
Trait
Title	Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
Risk Allele	G
P-val	4E-69
Odds Ratio	1.5300 [1.46-1.60]

[PMID 21209938 ] The NOD2 single nucleotide polymorphisms rs2066843 and rs2076756 are novel and common Crohn's disease susceptibility gene variants

GWAS snp
PMID	[PMID 22412388 ]
Trait
Title	A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
Risk Allele	G
P-val	1E-37
Odds Ratio	1.6600 None

[PMID 16600026 ] Asthma families show transmission disequilibrium of gene variants in the vitamin D metabolism and signalling pathway.

[PMID 18758464 ] Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease.

[PMID 19408013 ] Strategies and issues in the detection of pathway enrichment in genome-wide association studies.

[PMID 19434077 ] Detecting gene-gene interactions that underlie human diseases.

[PMID 21745515] Role of NOD1/CARD4 and NOD2/CARD15 gene polymorphisms in cancer etiology.

GWAS snp
PMID	[PMID 22936669]
Trait	Crohn's disease
Title	A genome-wide association study on a southern European population identifies a new Crohn's disease susceptibility locus at RBX1-EP300.
Risk Allele	G
P-val	3E-10
Odds Ratio	1.46 [NR]

[PMID 23725363] Predicting complicated Crohn's disease and surgery: phenotypes, genetics, serology and psychological characteristics of a population-based cohort.

[PMID 31714311] Clinical and Genetic Factors Impact Time to Surgical Recurrence After Ileocolectomy for Crohn Disease.