Have data from 23andMe or Ancestry? Make a report automatically with Promethease !

rs2238126

From SNPedia

Orientationplus
Stabilizedplus
Make rs2238126(A;A)
Make rs2238126(A;G)
Make rs2238126(G;G)
ReferenceGRCh38.p7 38.3/150
Chromosome12
Position11856807
GeneETV6
is asnp
is mentioned by
dbSNPrs2238126
dbSNP (old)rs2238126
ClinGenrs2238126
ebirs2238126
HLIrs2238126
Exacrs2238126
Gnomadrs2238126
Varsomers2238126
Maprs2238126
PheGenIrs2238126
Biobankrs2238126
1000 genomesrs2238126
hgdprs2238126
ensemblrs2238126
gopubmedrs2238126
geneviewrs2238126
scholarrs2238126
googlers2238126
pharmgkbrs2238126
gwascentralrs2238126
openSNPrs2238126
23andMers2238126
23andMe allrs2238126
SNPshotrs2238126
SNPdbers2238126
MSV3drs2238126
GWAS Ctlgrs2238126
Max Magnitude
? (A;A) (A;G) (G;G) 28

Chinese colorectal cancer risk, replicate in European ancestry:

To identify additional susceptibility loci for colorectal cancer, here we perform a GWAS in 1,023 cases and 1,306 controls and replicate the findings in seven independent samples from China, comprising 5,317 cases and 6,887 controls. We find a variant at 12p13.2 associated with colorectal cancer risk (rs2238126 in ETV6, P=2.67 × 10(-10)). We replicate this association in an additional 1,046 cases and 1,076 controls of European ancestry (P=0.034). The G allele of rs2238126 confers earlier age at onset of colorectal cancer (P=1.98 × 10(-6)) and reduces the binding affinity of transcriptional enhancer MAX.

PMID: https://www.ncbi.nlm.nih.gov/pubmed/27145994