|Less likely to suffer from vitamin D insufficiency|
|(A;C)||1||somewhat lower vitamin D levels|
|(C;C)||1.5||lower vitamin D levels|
In both studies, the allele associated with lower vitamin D, and thus the potential for vitamin D insufficiency, is rs2282679(C). Carriers of two such alleles have lower vitamin D than carriers of one allele, who in turn on average have lower vitamin D levels than rs2282679(A;A) individuals.10.1016/S0140-6736(10)60588-0
A near-perfect proxy (i.e. substitute) for rs2282679 is reported to be rs4588, which was the variant originally used along with rs7041 to define three alternative vitamin D binding protein forms. rs2282679(A) is typically co-inherited with rs4588(C); rs2282679(C) is typically co-inherited with rs4588(A).
|Trait||Vitamin D levels|
|Title||Genome-wide association study of circulating vitamin D levels|
|Odds Ratio||0.38 [0.32-0.44] unit decrease|
|Trait||Vitamin D insufficiency|
|Title||Common genetic determinants of vitamin D insufficiency: a genome-wide association study.|
|Odds Ratio||None None|
[PMID 19255064] Vitamin D-related genes, serum vitamin D concentrations and prostate cancer risk.
[PMID 21972121] Associations between common variants in GC and DHCR7/NADSYN1 and vitamin D concentration in Chinese Hans.
[PMID 22613962] Genetic Influences on Vitamin D Status and Forearm Fracture Risk in African American Children.
|Title||Genome-wide association analysis of circulating vitamin D levels in children with asthma.|
|Odds Ratio||None None|
[PMID 22704802] Vitamin D-binding protein (group-specific component) has decreased expression in rheumatoid arthritis
[PMID 22701574] Instrumental variable estimation of the causal effect of plasma 25-hydroxy-vitamin D on colorectal cancer risk: a mendelian randomization analysis
[PMID 23505139] An analysis of the association between the vitamin D pathway and serum 25-hydroxyvitamin D levels in a healthy Chinese population
[PMID 23734184] Genetic Analyses Reveal a Role for Vitamin D Insufficiency in HCV-Associated Hepatocellular Carcinoma Development
[PMID 23924835] Genetic variant in vitamin D binding protein is associated with serum 25-hydroxyvitamin D and vitamin D insufficiency in southern Chinese
[PMID 24007655] Genetic variants in Vitamin D pathway in Egyptian asthmatic children: a pilot study
[PMID 23456391] Serum vitamin D metabolites in colorectal cancer patients receiving cholecalciferol supplementation: correlation with polymorphisms in the vitamin D genes
[PMID 23191998] Genetic variations in the vitamin D binding protein and season-specific levels of vitamin D among older adults.
[PMID 23319826] Vitamin D and mortality: a Mendelian randomization study.
[PMID 23468552] Genetic variants influencing biomarkers of nutrition are not associated with cognitive capability in middle-aged and older adults.
[PMID 23793229] Association of common gene variants in vitamin D modulating genes and colon cancer recurrence.
[PMID 25032819] Vitamin D time profile based on the contribution of non-genetic and genetic factors in HIV-infected individuals of European ancestry
[PMID 25174667] Environmental and Genetic Determinants of Vitamin D Insufficiency in 12-month-old Infants
[PMID 25799011] Vitamin D Metabolic Pathway Genes and Pancreatic Cancer Risk
[PMID 25906790] Determinants of serum 25(OH)D concentration in young and middle-aged adults. The Cardiovascular Risk in Young Finns Study
[PMID 26209090] Vitamin D and prostate cancer prognosis: a Mendelian randomization study
[PMID 26448018] Variants in Vitamin D Binding Protein Gene Are Associated With Gestational Diabetes Mellitus
[PMID 27282160] GC and VDR SNPs and Vitamin D Levels in Parkinson's Disease: The Relevance to Clinical Features.
[PMID 27570856] Genetic influence on circulating vitamin D among Saudi Arabians.
[PMID 27594614] Association of vitamin D levels and risk of ovarian cancer: a Mendelian randomization study.
[PMID 28161065] Placental genetic variations in vitamin D metabolism and birthweight.
[PMID 28284354] Vitamin D-binding protein gene polymorphisms are not associated with MS risk in an Italian cohort.
[PMID 28278285] Genetic variant in vitamin D-binding protein is associated with metabolic syndrome and lower 25-hydroxyvitamin D levels in polycystic ovary syndrome: A cross-sectional study.
[PMID 29409465] Association of rs2282679 A>C polymorphism in vitamin D binding protein gene with colorectal cancer risk and survival: effect modification by dietary vitamin D intake.
[PMID 30150596] Association between Vitamin D Deficiency and Single Nucleotide Polymorphisms in the Vitamin D Receptor and GC Genes and Analysis of Their Distribution in Mexican Postmenopausal Women.
[PMID 31640710] DBP rs16846876 and rs12512631 polymorphisms are associated with progression to AIDS naïve HIV-infected patients: a retrospective study.
[PMID 32188599] Genetic predictors of circulating 25-hydroxyvitamin D and prognosis after colorectal cancer.
[PMID 32537819] Association between variants in vitamin D-binding protein gene and vitamin D deficiency among pregnant women in china.