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rs228697

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 0 common/normal
(C;G) 2 Somewhat more likely to prefer staying up late
(G;G) 2 Somewhat more likely to prefer staying up late
ReferenceGRCh38.p7 38.3/150
Chromosome1
Position7827519
GenePER3
is asnp
is mentioned by
dbSNPrs228697
dbSNP (old)rs228697
ClinGenrs228697
ebirs228697
HLIrs228697
Exacrs228697
Gnomadrs228697
Varsomers228697
LitVarrs228697
Maprs228697
PheGenIrs228697
Biobankrs228697
1000 genomesrs228697
hgdprs228697
ensemblrs228697
gopubmedrs228697
geneviewrs228697
scholarrs228697
googlers228697
pharmgkbrs228697
gwascentralrs228697
openSNPrs228697
23andMers228697
23andMe allrs228697
SNPshotrs228697
SNPdbers228697
MSV3drs228697
GWAS Ctlgrs228697
Max Magnitude2

Based on a study of 182 DSPT individuals, 67 free-running type (FRT) individuals, and 925 controls, all of whom were Japanese and between the ages of 20-40, a 2014 study concluded that rs228697(C;C) individuals were more likely to be "morning types" than "evening types", while rs228697(G) carriers were more common in evening types than in morning types (OR: 2.483; CI: 1.339–4.603, Bonferroni-corrected p = 0.012; crude p = 0.004). Similarly, the frequency of the G allele for rs228697 was significantly increased in FRT individuals compared with controls (OR: 2.021; CI: 1.160–3.524; permutated p = 0.017; crude p = 0.011).[PMID 25201053OA-icon.png]

? (C;C) (C;G) (G;G) 28

[PMID 25201053OA-icon.png] Screening of clock gene polymorphisms demonstrates association of a PER3 polymorphism with morningness-eveningness preference and circadian rhythm sleep disorder.