rs28371686
Warfarin (Coumadin®) |
Orientation | plus |
Stabilized | plus |
Geno | Mag | Summary |
---|---|---|
(C;C) | 0 | normal |
(C;G) | carrier of one CYP2C9*5 allele | |
(G;G) | 2.5 | CYP2C9*5 homozygote |
Reference | GRCh38 38.1/142 |
Chromosome | 10 |
Position | 94981301 |
Gene | CYP2C9 |
is a | snp |
is | mentioned by |
dbSNP | rs28371686 |
dbSNP (classic) | rs28371686 |
ClinGen | rs28371686 |
ebi | rs28371686 |
HLI | rs28371686 |
Exac | rs28371686 |
Gnomad | rs28371686 |
Varsome | rs28371686 |
LitVar | rs28371686 |
Map | rs28371686 |
PheGenI | rs28371686 |
Biobank | rs28371686 |
1000 genomes | rs28371686 |
hgdp | rs28371686 |
ensembl | rs28371686 |
geneview | rs28371686 |
scholar | rs28371686 |
rs28371686 | |
pharmgkb | rs28371686 |
gwascentral | rs28371686 |
openSNP | rs28371686 |
23andMe | rs28371686 |
SNPshot | rs28371686 |
SNPdbe | rs28371686 |
MSV3d | rs28371686 |
GWAS Ctlg | rs28371686 |
GMAF | 0.005051 |
Max Magnitude | 2.5 |
This SNP has been recognized by the Coriell Personalized Medicine Collaborative ICOB.
|
rs28371686, also known as 1080C>G, 42619C>G or D360E, is a SNP in the CYP2C9 gene.
The rs28371686(G) allele defines the CYP2C9*5 variant, which appears to have decreased activity.
[PMID 20214591] Pharmacogenomics in aspirin intolerance
[PMID 18466099] Influence of CYP2C9 and VKORC1 on warfarin dose, anticoagulation attainment and maintenance among European-Americans and African-Americans.
[PMID 18752379] Warfarin pharmacogenetics.
[PMID 23133420] Pharmacogenomic Diversity among Brazilians: Influence of Ancestry, Self-Reported Color, and Geographical Origin.
ClinVar | |
---|---|
Risk | rs28371686(A;A) Rs28371686(G;G) |
Alt | rs28371686(A;A) Rs28371686(G;G) |
Reference | Rs28371686(C;C) |
Significance | Other |
Disease | warfarin response - Dosage not provided |
Variation | info |
Gene | CYP2C9 |
CLNDBN | warfarin response - Dosage not provided |
Reversed | 0 |
HGVS | NC_000010.10:g.96741058C>G |
CLNSRC | PharmGKB Clinical Annotation |
CLNACC | RCV000211141.1, RCV000308849.1, |