rs3093061

Orientation

minus

Stabilized

minus

Geno	Mag	Summary
(A;A)	0	normal risk
(A;G)		normal risk?
(G;G)		0.37-0.49x reduced risk for SLE

Reference

GRCh38 38.1/142

Chromosome

1

Position

159715192

Gene

CRP

is a	snp
is	mentioned by
dbSNP	rs3093061
dbSNP (classic)	rs3093061
ClinGen	rs3093061
ebi	rs3093061
HLI	rs3093061
Exac	rs3093061
Gnomad	rs3093061
Varsome	rs3093061
LitVar	rs3093061
Map	rs3093061
PheGenI	rs3093061
Biobank	rs3093061
1000 genomes	rs3093061
hgdp	rs3093061
ensembl	rs3093061
geneview	rs3093061
scholar	rs3093061
google	rs3093061
pharmgkb	rs3093061
gwascentral	rs3093061
openSNP	rs3093061
23andMe	rs3093061
SNPshot	rs3093061
SNPdbe	rs3093061
MSV3d	rs3093061
GWAS Ctlg	rs3093061

Max Magnitude

0

rs3093061 is a SNP in the promoter of the C-reactive protein CRP gene.

[PMID 18182444] rs3093061 associated with SLE and functional haplotypes containing rs3091244/rs3093062

A study of ~1,000 patients with systemic lupus erythematosus found that in both populations (Caucasian and African-American) studied, the rs3093061(G;G) genotype had a significantly reduced risk compared to the more common (A;A) genotype. In African-Americans, the odds ratio was 0.49 (CI: 0.37-0.65, p=6.4x10e-7), and in Caucasians, the odds ratio was 0.37 (CI: 0.24-0.56, p=2.3x10e-6).

OMIM	613145
Desc
Variant
Related	also

[PMID 18216863] Genetic determinants of basal C-reactive protein expression in Filipino systemic lupus erythematosus families.

[PMID 29556849] C-reactive protein (CRP) polymorphisms and haplotypes are associated with SLE susceptibility and activity but not with serum CRP levels in Mexican population.