rs3131296

Orientation

minus

Stabilized

minus

Geno	Mag	Summary
(A;A)	0	normal risk for developing schizophrenia
(A;G)	1.2	1.2x increased risk for schizophrenia
(G;G)	1.4	1.4x increased risk for schizophrenia

Reference

GRCh38 38.1/141

Chromosome

6

Position

32205216

Gene

NOTCH4

is a	snp
is	mentioned by
dbSNP	rs3131296
dbSNP (classic)	rs3131296
ClinGen	rs3131296
ebi	rs3131296
HLI	rs3131296
Exac	rs3131296
Gnomad	rs3131296
Varsome	rs3131296
LitVar	rs3131296
Map	rs3131296
PheGenI	rs3131296
Biobank	rs3131296
1000 genomes	rs3131296
hgdp	rs3131296
ensembl	rs3131296
geneview	rs3131296
scholar	rs3131296
google	rs3131296
pharmgkb	rs3131296
gwascentral	rs3131296
openSNP	rs3131296
23andMe	rs3131296
SNPshot	rs3131296
SNPdbe	rs3131296
MSV3d	rs3131296
GWAS Ctlg	rs3131296

GMAF

0.06887

Max Magnitude

1.4

?	(A;A) (A;G) (G;G)	28

23andMe blog schizophrenia

• rs3131296(C) increased the odds of schizophrenia by 1.19x
• rs12807809(T) increased the odds of schizophrenia by 1.15x
• rs9960767(C) increased the odds of schizophrenia by 1.23 times.

[PMID 20673877] A study of ~2,500 Han Chinese patients with schizophrenia did find rs3131296 to be significantly associated in this population.

GWAS snp
PMID	[PMID 19571808]
Trait	Schizophrenia
Title	Common variants conferring risk of schizophrenia
Risk Allele	G
P-val	2E-10
Odds Ratio	1.19 [NR]

[PMID 18204098] Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX.

[PMID 19343178] Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size.

[PMID 23053058] Search for schizophrenia susceptibility variants at the HLA-DRB1 locus among a British population

[PMID 22005930] Genome-wide association study of Alzheimer's disease with psychotic symptoms.

[PMID 25142293] Association between the NOTCH4 gene rs3131296 polymorphism with schizophrenia risk in the Chinese Zhuang population and Chinese Han population