|(-;-)||4||very resistant to HIV|
|(-;GTCAGTATCAATTCTGGAAGAATTTCCAGACA)||2||resistant to HIV|
The chemokine receptor gene CCR5 plays an important role in many immune-related processes. Delta 32 rs333, designating the CCR5-delta32 deletion of 32 nucleotides from within the gene, is perhaps the most famous allele of CCR5. 23andMe tests for this under their private identifier/name, I3003626.
Individuals carrying one copy of the delta 32 allele are somewhat resistant to infection by HIV, the virus that causes AIDS, and individuals with 2 copies (delta 32 homozygotes, ~1% of Caucasians) are almost completely immune to infection by HIV. [PMID 8898752] The delta 32 allele may have been selected for in European populations because it confers resistance to plague (Black Death) or smallpox. 
Does the CCR5-delta32 mutation have an entirely positive/protective role?
Probably not. In patients with abdominal aortic aneurysm (AAA), the major risk is a sudden rupture - which is quite often fatal. Individuals with the delta 32 variant are more likely to have aneurysms than non-carriers, and among patients with aneurysms, delta 32 carriers are more likely to rupture than to be diagnosed in time for surgical repair. [PMID 15557916]
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|Disease||Human immunodeficiency virus type 1 West nile virus Resistance to hepatitis C virus Multiple sclerosis modifier of disease progression|
|CLNDBN||Human immunodeficiency virus type 1, susceptibility to West nile virus, susceptibility to Resistance to hepatitis C virus Multiple sclerosis modifier of disease progression|
|CLNSRC||OMIM Allelic Variant|
|CLNACC||RCV000008663.4, RCV000008664.3, RCV000008665.5, RCV000008666.4,|
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