rs3793917

Orientation

minus

Stabilized

minus

Make rs3793917(C;C)

Make rs3793917(C;G)

Make rs3793917(G;G)

Reference

GRCh38 38.1/142

Chromosome

10

Position

122459759

Gene	HTRA1, LOC105378525

is a	snp
is	mentioned by
dbSNP	rs3793917
dbSNP (classic)	rs3793917
ClinGen	rs3793917
ebi	rs3793917
HLI	rs3793917
Exac	rs3793917
Gnomad	rs3793917
Varsome	rs3793917
LitVar	rs3793917
Map	rs3793917
PheGenI	rs3793917
Biobank	rs3793917
1000 genomes	rs3793917
hgdp	rs3793917
ensembl	rs3793917
geneview	rs3793917
scholar	rs3793917
google	rs3793917
pharmgkb	rs3793917
gwascentral	rs3793917
openSNP	rs3793917
23andMe	rs3793917
SNPshot	rs3793917
SNPdbe	rs3793917
MSV3d	rs3793917
GWAS Ctlg	rs3793917

GMAF

0.2796

Max Magnitude

0

?	(C;C) (C;G) (G;G)	28

nature age related macular degeneration is associated with five highly correlated SNPs (rs10490924, rs3750848, rs3793917, rs11200638 and rs932275; r2 < 0.88) showed strongest association with AMD (2.72 < OR < 2.86)

[PMID 19933195] Analysis of six genetic risk factors highly associated with AMD in the region surrounding ARMS2 and HTRA1 on chromosome 10q26

GWAS snp
PMID	[PMID 20385819]
Trait	Age-related macular degeneration
Title	Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration
Risk Allele	G
P-val	4E-60
Odds Ratio	3.40 [2.94-3.94]

[PMID 17884985] A variant of mitochondrial protein LOC387715/ARMS2, not HTRA1, is strongly associated with age-related macular degeneration.

[PMID 20140183] Genetic and functional dissection of HTRA1 and LOC387715 in age-related macular degeneration.

[PMID 20445115] An intergenic region between the tagSNP rs3793917 and rs11200638 in the HTRA1 gene indicates association with age-related macular degeneration.

[PMID 21878851] Association between high-risk disease loci and response to anti-vascular endothelial growth factor treatment for wet age-related macular degeneration.

[PMID 22618592] Association of genetic polymorphisms and age-related macular degeneration in chinese population.

[PMID 23582991] Genetic Influences on the Outcome of Anti-Vascular Endothelial Growth Factor Treatment in Neovascular Age-related Macular Degeneration

GWAS snp
PMID	[PMID 23326517]
Trait	Age-related macular degeneration
Title	Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis.
Risk Allele
P-val	4E-24
Odds Ratio	1.45 [1.35-1.56]

[PMID 24013816] Cumulative association between age-related macular degeneration and less studied genetic variants in PLEKHA1/ARMS2/HTRA1: a meta and gene-cluster analysis

[PMID 26681391] Reticular Pseudodrusen and Their Association with Age-Related Macular Degeneration: The Melbourne Collaborative Cohort Study.