Geno
|
Mag
|
Summary
|
(C;C)
|
|
1.16x increased risk for type-2 diabetes
|
(C;T)
|
|
1.16x increased risk for type-2 diabetes
|
(T;T)
|
0
|
normal
|
[PMID 18477659] rs3802177 replicated as significant for type-2 diabetes risk in 1,900 Japanese patients, with odds ratio of 1.16 (CI: 1.05-1.27, p = 4.5 x 10e-3)
Note: this SNP is fairly tightly linked (r2 = 0.83) to another SNP in the SLC30A8 gene also linked to type-2 diabetes, rs13266634
GWAS snp
|
PMID
|
[PMID 20581827]
|
Trait
|
Type 2 diabetes
|
Title
|
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
|
Risk Allele
|
G
|
P-val
|
1E-8
|
Odds Ratio
|
1.15 [1.10-1.21]
|
[PMID 18469204] Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians.
[PMID 20550665] Association study of genetic variants in eight genes/loci with type 2 diabetes in a Han Chinese population.
[PMID 20554072] Gestational diabetes mellitus screening based on the gene chip technique.
GWAS snp
|
PMID
|
[PMID 22693455]
|
Trait
|
|
Title
|
Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases.
|
Risk Allele
|
G
|
P-val
|
4E-8
|
Odds Ratio
|
1.2300 None
|
GWAS snp
|
PMID
|
[PMID 24509480]
|
Trait
|
Type 2 diabetes
|
Title
|
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
|
Risk Allele
|
G
|
P-val
|
2E-18
|
Odds Ratio
|
1.16 [1.11-1.22]
|