rs3814637
Orientation | plus |
Stabilized | plus |
Geno | Mag | Summary |
---|---|---|
(C;C) | 0 |
Make rs3814637(C;T) |
Make rs3814637(T;T) |
Reference | GRCh38 38.1/142 |
Chromosome | 10 |
Position | 94761288 |
Gene | CYP2C19 |
is a | snp |
is | mentioned by |
dbSNP | rs3814637 |
dbSNP (classic) | rs3814637 |
ClinGen | rs3814637 |
ebi | rs3814637 |
HLI | rs3814637 |
Exac | rs3814637 |
Gnomad | rs3814637 |
Varsome | rs3814637 |
LitVar | rs3814637 |
Map | rs3814637 |
PheGenI | rs3814637 |
Biobank | rs3814637 |
1000 genomes | rs3814637 |
hgdp | rs3814637 |
ensembl | rs3814637 |
geneview | rs3814637 |
scholar | rs3814637 |
rs3814637 | |
pharmgkb | rs3814637 |
gwascentral | rs3814637 |
openSNP | rs3814637 |
23andMe | rs3814637 |
23andMe all | rs3814637 |
SNPshot | rs3814637 |
SNPdbe | rs3814637 |
MSV3d | rs3814637 |
GWAS Ctlg | rs3814637 |
GMAF | 0.07897 |
Max Magnitude | 0 |
rs3814637 represents an intronic variant in the CYP2C19 gene. Although found within several CYP2C19 star alleles (CYP2C19*1.004, CYP2C19*1.005, and CYP2C19*15.001) that have normal function, the minor (T) allele of rs3814637 is associated with significantly lower maintenance doses of warfarin among UK BioBank participants.10.1101/2020.08.09.243311
? | (C;C) (C;T) (T;T) | 28 |
---|---|---|
|
[PMID 21692828] The Population Pharmacokinetics of R and S-Warfarin: Effect of Genetic and Clinical Factors
[PMID 17048007] Association of warfarin dose with genes involved in its action and metabolism.
[PMID 18574025] The largest prospective warfarin-treated cohort supports genetic forecasting.
[PMID 23941071] Association of genetic polymorphisms with warfarin dose requirements in Chinese patients