|(C;T)||1.1||1.15x increased risk for late-onset Alzheimer's|
|(T;T)||1.2||1.2x increased risk for late-onset Alzheimer's|
|?||(C;C) (C;T) (T;T)||28|
rs3818361 is a SNP associated with the complement component (3b/4b) receptor 1 CR1 gene.
[PMID 20554627] The association of this SNP and late-onset Alzheimer's disease was replicated over a total of another 1829 cases (and 2576 controls). The odds ratio for rs3818361(T) allele was 1.15 (note the p value was 0.014).
[PMID 20558149] Complement receptor 1 polymorphisms and risk of late onset Alzheimer's disease
[PMID 20697030] Meta-analysis Confirms CR1, CLU, and PICALM as Alzheimer Disease Risk Loci and Reveals Interactions With APOE Genotypes
[PMID 21321396] Replication of BIN1 Association with Alzheimer's Disease and Evaluation of Genetic Interactions
|Title||Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease|
|Odds Ratio||1.1800 [1.13-1.24]|
[PMID 19734902] Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease.
[PMID 21379329] Genome-wide association of familial late-onset Alzheimer's disease replicates BIN1 and CLU and nominates CUGBP2 in interaction with APOE.
[PMID 21390209] Meta-analysis for genome-wide association study identifies multiple variants at the BIN1 locus associated with late-onset Alzheimer's disease.
[PMID 22244847] Alzheimer's disease risk factor complement receptor 1 is associated with depression.
[PMID 22402018] Implication of common and disease specific variants in CLU, CR1, and PICALM
[PMID 23419238] Allele-specific polymerase chain reaction for the detection of Alzheimer's disease-related single nucleotide polymorphisms
[PMID 22430674] Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer's disease.
[PMID 23022416] Effect of complement CR1 on brain amyloid burden during aging and its modification by APOE genotype.
[PMID 24998857] CR1 is potentially associated with rate of decline in sporadic Alzheimer's disease
[PMID 27103528] Association of genetic risk factors with cognitive decline: the PATH through life project.
[PMID 28316001] Associations of polymorphisms in the candidate genes for Alzheimer's disease BIN1, CLU, CR1 and PICALM with gestational diabetes and impaired glucose tolerance.