Region with strongest linkage for ability to discriminate pitch found in study of 767 Finnish individuals belonging in 76 families [PMID 24614497], involved in musical aptitude. Posterior Probability of Linkage given as 86% to trait Carl Seashore's subtest of pitch (SP).
Located next to the region harboring the protocadherin 7 gene, PCDH7 which has been suggested to play a role in cochlear and amygdaloid complexes. This SNP is in LIMCH1 LIM and calponin homology domains 1 gene, which is thought to be unlikely to be responsible, probably a combination of SNP's frequently inherited with it are involved. The study suggests rs13146789 in PCDH7 as one likely causal variant.
[PMID 24614497] A genome-wide linkage and association study of musical aptitude identifies loci containing genes related to inner ear development and neurocognitive functions.