rs4402960

plus

Geno	Mag	Summary
(G;G)	0	normal
(G;T)	2	1.2x increased risk for type-2 diabetes, ~1x risk for gestational diabetes
(T;T)	2.1	1.2x increased risk for type-2 diabetes, 1.5x risk for gestational diabetes

Reference

GRCh38 38.1/141

Chromosome

3

Position

185793899

Gene

IGF2BP2

is a	snp
is	mentioned by
dbSNP	rs4402960
dbSNP (classic)	rs4402960
ClinGen	rs4402960
ebi	rs4402960
HLI	rs4402960
Exac	rs4402960
Gnomad	rs4402960
Varsome	rs4402960
LitVar	rs4402960
Map	rs4402960
PheGenI	rs4402960
Biobank	rs4402960
1000 genomes	rs4402960
hgdp	rs4402960
ensembl	rs4402960
geneview	rs4402960
scholar	rs4402960
google	rs4402960
pharmgkb	rs4402960
gwascentral	rs4402960
openSNP	rs4402960
23andMe	rs4402960
SNPshot	rs4402960
SNPdbe	rs4402960
MSV3d	rs4402960
GWAS Ctlg	rs4402960

GMAF

0.343

Max Magnitude

2.1

?

(G;G) (G;T) (T;T)

28

[PMID 18477659] rs4402960 replicated as significant for type-2 diabetes risk in 1,900 Japanese patients, with odds ratio of 1.23 (CI: 1.11-1.36, p = 8.1 x 10e-5)

[PMID 17463248 ] associated with type-2 diabetes

[PMID 18162508] significantly associated with type-2 diabetes p = 0.00009; in 1,630 Japanese subjects and in 1,064 controls

[PMID 18437351] 1,638 type-2 diabetes patients and 1,858 controls

rs4402960 borderline (OR 1.10, 95% CI: 0.99-1.22).

[PMID 18430866 ] Neither rs4402960 or rs1470579 were found to be associated with type-2 diabetes in a study of 3,000 French Caucasians.

[PMID 19033397 ] This SNP was confirmed to be associated with type-2 diabetes in a study of 500+ Japanese patients plus pooled meta-analysis with 6 previous association studies (also of Japanese).

Note: rs4402960 is fairly tightly linked (r²=0.87) with another IGF2BP2 gene SNP also associated with type-2 diabetes, rs1470579

Called into question by table 1 of 10.1371/journal.pbio.1000294

GWAS
SNP	rs4402960
PubMedID	[PMID 17463249 ]
Condition	Type 2 diabetes
Gene	IGF2BP2
Risk Allele	T
pValue	9.00E-016
OR	1.14
95% CI	1.11-1.18

[PMID 19258437 ] A Genetic Variant in the IGF2BP2 Gene may Interact with Fetal Malnutrition on Glucose Metabolism.

GWAS snp
PMID	[PMID 18372903 ]
Trait	Type 2 diabetes
Title	Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
Risk Allele	T
P-val	8.0000000000000002E-8
Odds Ratio	1.17 [1.10-1.25]

GWAS snp
PMID	[PMID 17463246]
Trait	Type 2 diabetes
Title	Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
Risk Allele	T
P-val	9.0000000000000003E-16
Odds Ratio	1.14 [1.11-1.18]

GWAS snp
PMID	[PMID 19401414 ]
Trait	Type 2 diabetes
Title	Confirmation of multiple risk loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population
Risk Allele	T
P-val	0.000001
Odds Ratio	1.14 [1.08-1.21]

OMIM	608289
Desc	INSULIN-LIKE GROWTH FACTOR 2 mRNA-BINDING PROTEIN 2; IGF2BP2
Variant
Related	also

[PMID 20043145 ] Improvements in glucose homeostasis in response to regular exercise are influenced by the PPARG Pro12Ala variant: results from the HERITAGE Family Study

[PMID 20215779] Evidence of Interaction between Type 2 Diabetes Susceptibility Genes and Dietary Fat Intake for Adiposity and Glucose Homeostasis-Related Phenotypes

[PMID 20523342 ] IGF2BP2 variations influence repaglinide response and risk of type 2 diabetes in Chinese population

[PMID 20384434] Combining genetic markers and clinical risk factors improves the risk assessment of impaired glucose metabolism

[PMID 20802253 ] Glycemia determines the effect of type 2 diabetes risk genes on insulin secretion

OMIM	608289
Desc
Variant	0001
Related	also

[PMID 22032244] IGF2BP2 Genetic Variation and Type 2 Diabetes: A Global Meta-Analysis

[PMID 22096510 ] Association of six single nucleotide polymorphisms with gestational diabetes mellitus in a chinese population

[PMID 22419714] Effect of Type 2 Diabetes Predisposing Genetic Variants on Colorectal Cancer Risk

[PMID 22569928 ] Analysis of common type 2 diabetes mellitus genetic risk factors in new-onset diabetes after transplantation in kidney transplant patients medicated with tacrolimus

[PMID 17786212 ] Heterogeneity in meta-analyses of genome-wide association investigations.

[PMID 17827400] Studies of association of variants near the HHEX, CDKN2A/B, and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10,705 Danish subjects: validation and extension of genome-wide association studies.

[PMID 18224312 ] Pharmacogenetics: data, concepts and tools to improve drug discovery and drug treatment.

[PMID 18264689] Polymorphisms in the TCF7L2, CDKAL1 and SLC30A8 genes are associated with impaired proinsulin conversion.

[PMID 18319073 ] Using the optimal receiver operating characteristic curve to design a predictive genetic test, exemplified with type 2 diabetes.

[PMID 18423522 ] Estimating odds ratios in genome scans: an approximate conditional likelihood approach.

[PMID 18426861 ] Association analysis of type 2 diabetes Loci in type 1 diabetes.

[PMID 18443202 ] Association analysis in african americans of European-derived type 2 diabetes single nucleotide polymorphisms from whole-genome association studies.

[PMID 18461161 ] Post genome-wide association studies of novel genes associated with type 2 diabetes show gene-gene interaction and high predictive value.

[PMID 18469204 ] Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians.

[PMID 18533027 ] Worldwide population differentiation at disease-associated SNPs.

[PMID 18544707 ] Extension of type 2 diabetes genome-wide association scan results in the diabetes prevention program.

[PMID 18591388 ] Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk.

[PMID 18633108 ] Common variants in CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, and HHEX/IDE genes are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population.

[PMID 18689899 ] Exchangeable models of complex inherited diseases.

[PMID 18694974 ] Predicting type 2 diabetes based on polymorphisms from genome-wide association studies: a population-based study.

[PMID 18782870 ] Clinical review: the genetics of type 2 diabetes: a realistic appraisal in 2008.

[PMID 18852197 ] Metabolic and cardiovascular traits: an abundance of recently identified common genetic variants.

[PMID 18991055] Association between polymorphisms in SLC30A8, HHEX, CDKN2A/B, IGF2BP2, FTO, WFS1, CDKAL1, KCNQ1 and type 2 diabetes in the Korean population.

[PMID 19002430] Type 2 diabetes-associated genetic variants discovered in the recent genome-wide association studies are related to gestational diabetes mellitus in the Korean population.

[PMID 19008344 ] Association analysis of variation in/near FTO, CDKAL1, SLC30A8, HHEX, EXT2, IGF2BP2, LOC387761, and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians.

[PMID 19056611 ] Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data.

[PMID 19096518 ] Novel association of HK1 with glycated hemoglobin in a non-diabetic population: a genome-wide evaluation of 14,618 participants in the Women's Genome Health Study.

[PMID 19207020 ] Meta-analysis in genome-wide association studies.

[PMID 19228808 ] Type 2 diabetes risk alleles are associated with reduced size at birth.

[PMID 19279076 ] Genetic predisposition, Western dietary pattern, and the risk of type 2 diabetes in men.

[PMID 19323962 ] Genome-wide association studies in type 2 diabetes.

[PMID 19324937 ] Previously associated type 2 diabetes variants may interact with physical activity to modify the risk of impaired glucose regulation and type 2 diabetes: a study of 16,003 Swedish adults.

[PMID 19341491 ] Genome-based prediction of common diseases: methodological considerations for future research.

[PMID 19455305 ] No association of multiple type 2 diabetes loci with type 1 diabetes.

[PMID 19460916 ] Genetic architecture of type 2 diabetes: recent progress and clinical implications.

[PMID 19502414 ] Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men.

[PMID 19526209 ] Is the thrifty genotype hypothesis supported by evidence based on confirmed type 2 diabetes- and obesity-susceptibility variants?

[PMID 19602701 ] Underlying genetic models of inheritance in established type 2 diabetes associations.

[PMID 19741467] Association of common type 2 diabetes risk gene variants and posttransplantation diabetes mellitus in renal allograft recipients in Korea.

[PMID 19902174 ] Diet-induced gene expression of isolated pancreatic islets from a polygenic mouse model of the metabolic syndrome.

[PMID 19931040 ] Simultaneous genotype calling and haplotype phasing improves genotype accuracy and reduces false-positive associations for genome-wide association studies.

[PMID 19956539 ] How many genetic variants remain to be discovered?

[PMID 20017978 ] Influence of control selection in genome-wide association studies: the example of diabetes in the Framingham Heart Study.

[PMID 20018066 ] Epistatic interactions of CDKN2B-TCF7L2 for risk of type 2 diabetes and of CDKN2B-JAZF1 for triglyceride/high-density lipoprotein ratio longitudinal change: evidence from the Framingham Heart Study.

[PMID 20049090 ] Association between type 2 diabetes loci and measures of fatness.

[PMID 20126254 ] Rare variants create synthetic genome-wide associations.

[PMID 20142250 ] Diabetes genes and prostate cancer in the Atherosclerosis Risk in Communities study.

[PMID 20144327 ] A genomics study of type 2 diabetes mellitus in U.S. Air Force personnel.

[PMID 20161779 ] Investigation of type 2 diabetes risk alleles support CDKN2A/B, CDKAL1, and TCF7L2 as susceptibility genes in a Han Chinese cohort.

[PMID 20424228 ] Impact of common variants of PPARG, KCNJ11, TCF7L2, SLC30A8, HHEX, CDKN2A, IGF2BP2, and CDKAL1 on the risk of type 2 diabetes in 5,164 Indians.

[PMID 20509872 ] Implication of genetic variants near SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, FTO, TCF2, KCNQ1, and WFS1 in type 2 diabetes in a Chinese population.

[PMID 20532014 ] The epidemiology of diabetes in Korea: from the economics to genetics.

[PMID 20550665 ] Association study of genetic variants in eight genes/loci with type 2 diabetes in a Han Chinese population.

[PMID 20712903 ] Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study.

[PMID 21278902 ] Genetic risk profiling for prediction of type 2 diabetes.

[PMID 21283728 ] Genetic variants of diabetes risk and incident cardiovascular events in chronic coronary artery disease.

[PMID 22015911] Quantitative assessment of the variation in IGF2BP2 gene and type 2 diabetes risk.

[PMID 22245690] Strong association of common variants in the IGF2BP2 gene with type 2 diabetes in Lebanese Arabs.

GWAS snp
PMID	[PMID 22693455 ]
Trait
Title	Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases.
Risk Allele	T
P-val	3E-9
Odds Ratio	1.1500 None

[PMID 23403707 ] The rs11705701 G>A Polymorphism of IGF2BP2 is Associated With IGF2BP2 mRNA and Protein Levels in the Visceral Adipose Tissue - A Link to Type 2 Diabetes Susceptibility

[PMID 23029294 ] Meta-analysis of the relationship between common type 2 diabetes risk gene variants with gestational diabetes mellitus

[PMID 23690305 ] Genetic variants and the risk of gestational diabetes mellitus: a systematic review

[PMID 22923468 ] Contribution of common genetic variation to the risk of type 2 diabetes in the Mexican Mestizo population.

[PMID 23298195] Association study of genetic variants of 17 diabetes-related genes/loci and cardiovascular risk and diabetic nephropathy in the Chinese She population.

[PMID 23458876] ACE I/D and MTHFR C677T polymorphisms are significantly associated with type 2 diabetes in Arab ethnicity: a meta-analysis.

[PMID 25062844 ] IGF2BP2 and obesity interaction analysis for type 2 diabetes mellitus in chinese han population

GWAS snp
PMID	[PMID 24509480 ]
Trait	Type 2 diabetes
Title	Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
Risk Allele	T
P-val	1E-17
Odds Ratio	1.13 [1.09-1.17]

ClinVar
Risk	Rs4402960(T;T)
Alt	Rs4402960(T;T)
Reference	Rs4402960(G;G)
Significance	Other
Disease	Diabetes mellitus type 2
Variation	info
Gene	IGF2BP2
CLNDBN	Diabetes mellitus type 2
Reversed	0
HGVS	NC_000003.11:g.185511687G>T
CLNSRC	OMIM Allelic Variant
CLNACC	RCV000002537.2,

[PMID 24959828 ] Genetic association study with metabolic syndrome and metabolic-related traits in a cross-sectional sample and a 10-year longitudinal sample of chinese elderly population

[PMID 25755232] Habitual coffee intake, genetic polymorphisms, and type 2 diabetes

[PMID 27310578 ] Replication and Relevance of Multiple Susceptibility Loci Discovered from Genome Wide Association Studies for Type 2 Diabetes in an Indian Population.

[PMID 29410390 ] Genes associated with Type 2 Diabetes and vascular complications.

[PMID 30371117] Effect of FTO and IGF2BP2 gene polymorphisms on duration of pregnancy and Apgar scores in women with gestational diabetes.