|(A;T)||1.5||1.4x increased risk for type-2 diabetes|
|(T;T)||2||1.9x increased risk for type-2 diabetes|
|?||(A;A) (A;T) (T;T)||28|
rs4506565 has been reported in a large study to be associated with type-2 diabetes.
The risk allele (oriented to the dbSNP entry) is (T); the odds ratio associated with heterozygotes is 1.36 (CI 1.2-1.54), and for homozygotes, 1.88 (CI 1.56-2.27). [PMID 17554300]
Note: this is one of two SNPs within the TCF7L2 gene that have been reported to be associated with type-2 diabetes, the other being rs7903146. They have approximately equal power to estimate risk for type-2 diabetes, and the results from one correlate 92% of the time with the other. [PMID 17554300]
[PMID 20018066] Epistatic interactions of CDKN2B-TCF7L2 for risk of type 2 diabetes and of CDKN2B-JAZF1 for triglyceride/high-density lipoprotein ratio longitudinal change: evidence from the Framingham Heart Study
|Trait||Fasting glucose-related traits|
|Title||New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk|
|Odds Ratio||None None|
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