||common in clinvar
Associated with lean body mass but not fat body mass in a study of ~1,800 Caucasians [PMID 18180959]
[PMID 19593234] Association analyses suggest multiple interaction effects of the methylenetetrahydrofolate reductase polymorphisms on timing of menarche and natural menopause in white women
[PMID 19493349] 118 SNPs of folate-related genes and risks of spina bifida and conotruncal heart defects.
[PMID 25566964] Polymorphisms in the MTHFR gene are associated with breast cancer risk and prognosis in a Chinese population
[PMID 31601265] Polymorphisms of MTHFR and TYMS predict capecitabine-induced hand-foot syndrome in patients with metastatic breast cancer.
[PMID 31750632] The SNP rs4846048 of MTHFR enhances the cervical cancer risk through association with miR-522: A preliminary report.
[PMID 32117640] Single nucleotide polymorphism of MTHFR rs1801133 associated with elevated Hcy levels affects susceptibility to cerebral small vessel disease.